CKDdb-logoCKDdb - Molecule ID A1702

geneAGT, SERPINA8
nameAngiotensinogen
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ANGT_HUMANP01019ENSG00000135744183Hs.19383106150, 145500, 267430

Functions and classifications

GOC:extracellular space, F:growth factor activity, F:hormone activity, F:serine-type endopeptidase inhibitor activity, P:activation of NF-kappaB-inducing kinase activity, P:activation of phospholipase C activity, P:aging, P:angiotensin maturation, P:angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure, P:angiotensin-mediated drinking behavior, P:artery smooth muscle contraction, P:astrocyte activation, P:blood vessel development, P:blood vessel remodeling, P:branching involved in ureteric bud morphogenesis, P:catenin import into nucleus, P:cell growth involved in cardiac muscle cell development, P:cell-cell signaling, P:cell-matrix adhesion, P:cellular lipid metabolic process, P:cellular protein metabolic process, P:cellular response to mechanical stimulus, P:cellular sodium ion homeostasis, P:cytokine secretion, P:ERK1 and ERK2 cascade, P:establishment of blood-nerve barrier, P:excretion, P:extracellular matrix organization, P:fibroblast proliferation, P:G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger, P:kidney development, P:low-density lipoprotein particle remodeling, P:negative regulation of angiogenesis, P:negative regulation of cell growth, P:negative regulation of cell proliferation, P:negative regulation of neuron apoptotic process, P:negative regulation of neurotrophin TRK receptor signaling pathway, P:negative regulation of tissue remodeling, P:nitric oxide mediated signal transduction, P:ovarian follicle rupture, P:peristalsis, P:phospholipase C-activating G-protein coupled receptor signaling pathway, P:positive regulation of activation of JAK2 kinase activity, P:positive regulation of branching involved in ureteric bud morphogenesis, P:positive regulation of cardiac muscle hypertrophy, P:positive regulation of cholesterol esterification, P:positive regulation of cytokine production, P:positive regulation of endothelial cell migration, P:positive regulation of epidermal growth factor receptor signaling pathway, P:positive regulation of extracellular matrix constituent secretion, P:positive regulation of extrinsic apoptotic signaling pathway, P:positive regulation of fatty acid biosynthetic process, P:positive regulation of fibroblast proliferation, P:positive regulation of inflammatory response, P:positive regulation of macrophage derived foam cell differentiation, P:positive regulation of MAPK cascade, P:positive regulation of multicellular organism growth, P:positive regulation of NAD(P)H oxidase activity, P:positive regulation of NF-kappaB transcription factor activity, P:positive regulation of organ growth, P:positive regulation of phosphatidylinositol 3-kinase signaling, P:positive regulation of protein tyrosine kinase activity, P:positive regulation of reactive oxygen species metabolic process, P:positive regulation of renal sodium excretion, P:positive regulation of superoxide anion generation, P:positive regulation of transcription, DNA-templated, P:regulation of blood vessel size by renin-angiotensin, P:regulation of calcium ion transport, P:regulation of cell growth, P:regulation of long-term neuronal synaptic plasticity, P:regulation of norepinephrine secretion, P:regulation of proteolysis, P:regulation of renal output by angiotensin, P:regulation of renal sodium excretion, P:regulation of vasoconstriction, P:renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure, P:renin-angiotensin regulation of aldosterone production, P:response to cold, P:response to muscle activity involved in regulation of muscle adaptation, P:response to salt stress, P:small molecule metabolic process, P:smooth muscle cell differentiation, P:smooth muscle cell proliferation, P:stress-activated MAPK cascade, P:uterine smooth muscle contraction, P:vasodilation, C:extracellular space, P:regulation of systemic arterial blood pressure by renin-angiotensin, P:G-protein coupled receptor signaling pathway, P:hormone metabolic process, P:positive regulation of gene expression, P:regulation of inflammatory response, P:vasodilation, C:cytoplasmic part, F:acetyltransferase activator activity, P:induction of apoptosis, P:negative regulation of nerve growth factor receptor signaling pathway, P:positive regulation of apoptotic process, P:positive regulation of phosphatidylinositol 3-kinase cascade, P:positive regulation of transcription, DNA-dependent, C:cytoplasmic part
UniProt3D-structure, Complete proteome, Direct protein sequencing, Disease mutation, Disulfide bond, Glycoprotein, Polymorphism, Reference proteome, Secreted, Signal, Vasoactive, Vasoconstrictor
PADBsignalling

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17301227Homo sapiens13bloodserumFabry (6 months of ERT) 0.1685nanoLC-ESI-MS/MS17301227
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.260.000225RNA microarray19698090
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy)up MS/MS, LTQ LX linear ion trap20093355
Exp20411046Homo sapiens5kidneycyst fluidPolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease) < 0.001LC-MS/MS20411046
Exp20639044aHomo sapiens46urinewholeureteral_obstruction (unilateral uteropelvic junction obstruction)22.21< 0.05LC-MS/MS20639044
Exp21183621Homo sapiens24bloodserumChronic_Renal_Insufficiency (Chronic kidney disease)3.20.0051ProtoArray human protein microarray V3, (Invitrogen, PAH052401)21183621
Exp23143504Homo sapiens urinewholeAKI (AKI)814.630.002LC-MS/MS23143504
Exp23228063Homo sapiens30urinewholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease)1.70.00003LC-MS/MS23228063
Exp23344851Rattus norvegicus14urineexosomeDiabetes (diabetic nephropathy)1.42 nLC-ESI-UHR-QToF-MS/MS23344851
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)0.46< 0.05RNA-seq23757392
Exp24096133aHomo sapiens10urine>10kDaDiabetes (type 1 diabetes without retinopathy or nephropathy)0 1DE, MALDI24096133
Exp24096133bHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy)0 1DE, MALDI24096133
Exp24096133cHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy and nephropathy)0 1DE, MALDI24096133
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)0.470.00199RNA microarray24569379
Exp25666440Homo sapiens23urinesupernatantFabry (naive Fabry patients)0.340.001529nanoLC-ESI-MS/MS25666440

Compile date 08-10-2018© iMODE-CKD consortium