CKDdb-logoCKDdb - Molecule ID A1623

geneC6
nameComplement component C6
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
CO6_HUMANP13671ENSG00000039537729Hs.481992217050, 612446

Functions and classifications

GOC:extracellular region, C:membrane attack complex, P:complement activation, P:complement activation, classical pathway, P:cytolysis, P:in utero embryonic development, P:innate immune response, P:positive regulation of activation of membrane attack complex, P:positive regulation of angiogenesis, P:regulation of complement activation, P:immune response, C:extracellular space, P:activation of cysteine-type endopeptidase activity involved in apoptotic process, P:induction of apoptosis, P:innate immune response
UniProt3D-structure, Complement pathway, Complete proteome, Cytolysis, Direct protein sequencing, Disulfide bond, EGF-like domain, Glycoprotein, Immunity, Innate immunity, Membrane attack complex, Polymorphism, Reference proteome, Repeat, Secreted, Signal, Sushi
PADBunknown

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090aHomo sapiens17bloodmononuclear cellsChronic_Renal_Insufficiency (Chronic kidney disease)0.480.0299522RNA microarray19698090
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy)up MS/MS, LTQ LX linear ion trap20093355
Exp20812764Homo sapiens13bloodplasmaTransplantation (Acute Renal Allograft Rejection)2.090.2322LC-MS/MS20812764
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)8.81< 0.05RNA-seq23757392

Compile date 08-10-2018© iMODE-CKD consortium