CKDdb-logoCKDdb - Molecule ID A1616

geneC5, CPAMD4
nameComplement C5 precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
CO5_HUMANP01031ENSP00000223642727Hs.494997120900, 609536

Functions and classifications

GOC:extracellular space, C:membrane attack complex, F:chemokine activity, F:endopeptidase inhibitor activity, P:activation of MAPK activity, P:cellular calcium ion homeostasis, P:chemotaxis, P:complement activation, P:complement activation, alternative pathway, P:complement activation, classical pathway, P:cytolysis, P:G-protein coupled receptor signaling pathway, P:glucose homeostasis, P:in utero embryonic development, P:inflammatory response, P:innate immune response, P:leukocyte migration involved in inflammatory response, P:negative regulation of dopamine secretion, P:negative regulation of endopeptidase activity, P:negative regulation of macrophage chemotaxis, P:negative regulation of norepinephrine secretion, P:positive regulation of angiogenesis, P:positive regulation of chemokine secretion, P:positive regulation of chemotaxis, P:positive regulation vascular endothelial growth factor production, P:regulation of complement activation, C:extracellular region, P:induction of apoptosis, P:positive regulation vascular endothelial growth factor production
UniProt3D-structure, Cleavage on pair of basic residues, Complement alternate pathway, Complement pathway, Complete proteome, Cytolysis, Direct protein sequencing, Disulfide bond, Glycoprotein, Immunity, Inflammatory response, Innate immunity, Membrane attack complex, Polymorphism, Reference proteome, Secreted, Signal
PADBmodulator, regulator

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp20007950aRattus norvegicus8corporawholeDiabetes (Diabetes Mellitus-associated Erectile Dysfunction)1.20.00051MALDI-TOF, LC-MS/MS20007950
Exp20007950bRattus norvegicus8corporawholeDiabetes (Diabetes Mellitus-associated Erectile Dysfunction)2.020.00051MALDI-TOF, LC-MS/MS20007950
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy)up MS/MS, LTQ LX linear ion trap20093355
Exp20543976Homo sapiens40urinewholeTransplantation (acute renal allograft rejection)3.3 LC-MS/MS20543976
Exp23228063Homo sapiens30urinewholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease)1.90.01113LC-MS/MS23228063
Exp25279147Homo sapiens12kidneybiopsy sectionGlomerulonephritis (IgA nephropathy)0.45< 0.05MALDI TOF/TOF25279147
Exp25769567Homo sapiens19kidneygraftsChronic_rejection (Chronic_rejection)1.74< 0.05ESI-TOF/TOF25769567

Compile date 08-10-2018© iMODE-CKD consortium