CKDdb-logoCKDdb - Molecule ID A160H

geneALOXE3
nameEpidermis-type lipoxygenase 3
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
LOXE3_HUMANQ9BYJ1ENSG0000017914859344Hs.232770606545, 607206, 242100

Functions and classifications

GOC:cytoplasm, F:hepoxilin A3 synthase activity, F:iron ion binding, F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, P:arachidonic acid metabolic process, P:ceramide biosynthetic process, P:establishment of skin barrier, P:fat cell differentiation, P:hepoxilin biosynthetic process, P:linoleic acid metabolic process, P:lipoxygenase pathway, P:peroxisome proliferator activated receptor signaling pathway, P:sensory perception of pain, F:metal ion binding, F:oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen, F:iron ion binding, F:lipoxygenase activity, P:leukotriene biosynthetic process, P:leukotriene metabolic process
UniProtAlternative splicing, Complete proteome, Cytoplasm, Dioxygenase, Disease mutation, Fatty acid metabolism, Ichthyosis, Iron, Isomerase, Lipid metabolism, Metal-binding, Oxidoreductase, Reference proteome, Leukotriene biosynthesis
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.170.0000169RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.410.0172RNA microarray19698090
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)4.320.000000764RNA microarray24569379

Compile date 08-10-2018© iMODE-CKD consortium