CKDdb-logoCKDdb - Molecule ID A1609

geneCALR, CRTC
nameCalreticulin precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
CALR_HUMANP27797ENSP00000320866811Hs.515162109091

Functions and classifications

GOC:acrosomal vesicle, C:cell surface, C:cytosol, C:endocytic vesicle lumen, C:endoplasmic reticulum lumen, C:external side of plasma membrane, C:extracellular space, C:Golgi apparatus, C:integral component of lumenal side of endoplasmic reticulum membrane, C:MHC class I peptide loading complex, C:nucleus, C:perinuclear region of cytoplasm, C:polysome, C:proteinaceous extracellular matrix, C:sarcoplasmic reticulum lumen, F:androgen receptor binding, F:calcium ion binding, F:carbohydrate binding, F:chaperone binding, F:complement component C1q binding, F:DNA binding, F:hormone binding, F:iron ion binding, F:mRNA binding, F:peptide binding, F:protein binding involved in protein folding, F:unfolded protein binding, F:zinc ion binding, P:activation of signaling protein activity involved in unfolded protein response, P:antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent, P:cardiac muscle cell differentiation, P:cell cycle arrest, P:cellular response to lithium ion, P:cellular senescence, P:chaperone-mediated protein folding, P:cortical actin cytoskeleton organization, P:glucocorticoid receptor signaling pathway, P:negative regulation of intracellular steroid hormone receptor signaling pathway, P:negative regulation of neuron differentiation, P:negative regulation of retinoic acid receptor signaling pathway, P:negative regulation of transcription from RNA polymerase II promoter, P:negative regulation of translation, P:peptide antigen assembly with MHC class I protein complex, P:positive regulation of cell cycle, P:positive regulation of cell proliferation, P:positive regulation of dendritic cell chemotaxis, P:positive regulation of DNA replication, P:positive regulation of gene expression, P:positive regulation of phagocytosis, P:positive regulation of substrate adhesion-dependent cell spreading, P:post-translational protein modification, P:protein export from nucleus, P:protein localization to nucleus, P:protein maturation by protein folding, P:protein N-linked glycosylation via asparagine, P:protein stabilization, P:regulation of apoptotic process, P:regulation of meiosis, P:response to drug, P:response to estradiol, P:response to testosterone, P:sequestering of calcium ion, P:spermatogenesis, C:extracellular matrix, C:sarcoplasmic reticulum, P:cellular response to organic substance, C:endoplasmic reticulum, P:protein folding, C:integral to lumenal side of endoplasmic reticulum membrane, P:response to estradiol stimulus, P:response to testosterone stimulus
UniProt3D-structure, Acetylation, Calcium, Chaperone, Complete proteome, Cytoplasm, Direct protein sequencing, Disulfide bond, Endoplasmic reticulum, Extracellular matrix, Glycoprotein, Lectin, Metal-binding, Reference proteome, Repeat, Sarcoplasmic reticulum, Secreted, Signal, Zinc
PADBCHA: chaperone, chaperonin

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17609286Mus musculus10kidneyglomeruliDiabetes (diabetic nephropathy in Type 1 diabetes) < 0.05MALDI-TOF-MS17609286
Exp19836472Mus musculus kidneytubule cellsDiabetes (Diabetic Nephropathy)0.26 LC-MS/MS19836472
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy)up MS/MS, LTQ LX linear ion trap20093355
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.7< 0.05RNA microarray21752957
Exp22536212Homo sapiens86urinewholeDiabetes (type 2 diabetic nephropathy)1.390hybrid quadrupole-TOF, LC-MS/MS22536212
Exp22595305aRattus norvegicus24kidney Glomerulonephritis (Passive Heymann nephritis)1.75< 0.05LC-MS/MS22595305
Exp22595305bRattus norvegicus24kidney Glomerulonephritis (Passive Heymann nephritis)0.87< 0.05LC-MS/MS22595305
Exp24067438Homo sapiens64urinewholeAKI (AKI)0.18< 0.05LC-ESI-MS/MS24067438
Exp24798088Rattus norvegicus kidney AKI (AKI)2.490.029MS/MS24798088
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.392.58E-04RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium