CKDdb-logoCKDdb - Molecule ID A1602

geneCFB, BF, BFD
nameComplement factor B precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
CFAB_HUMANP00751ENSP00000382862629Hs.69771138470, 603075, 612924

Functions and classifications

GOC:extracellular region, C:plasma membrane, F:complement binding, F:serine-type endopeptidase activity, P:complement activation, alternative pathway, P:proteolysis, P:regulation of complement activation, C:extracellular region, P:complement activation
UniProt3D-structure, Alternative splicing, Cleavage on pair of basic residues, Complement alternate pathway, Complete proteome, Direct protein sequencing, Disease mutation, Disulfide bond, Glycation, Glycoprotein, Hemolytic uremic syndrome, Hydrolase, Immunity, Innate immunity, Polymorphism, Protease, Reference proteome, Repeat, Secreted, Serine protease, Signal, Sushi, Zymogen
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17301227Homo sapiens13bloodserumFabry (6 months of ERT) 0.25nanoLC-ESI-MS/MS17301227
Exp18440303Rattus norvegicus20urineglycoproteinsGlomerulonephritis (adriamycin nephropathy and Thy1.1 induced glomerulonephritis)>100 LC-MS/MS18440303
Exp18440303Rattus norvegicus20urineglycoproteinsGlomerulonephritis (adriamycin nephropathy and Thy1.1 induced glomerulonephritis)0.22 LC-MS/MS18440303
Exp20411046Homo sapiens5kidneycyst fluidPolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease) 1.00E-04LC-MS/MS20411046
Exp20847290Homo sapiens30kidneyglomeruliGlomerulonephritis (FSGS + COLL)3.730.0925RNA microarray20847290
Exp21411733aMus musculus13macrophageF4/80hi cellsGlomerulonephritis (lupus nephritis)4.590cDNA microarray21411733
Exp21411733bMus musculus11macrophageF4/80hi cellsGlomerulonephritis (lupus nephritis)0.290cDNA microarray21411733
Exp21544065cRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D)1.390.04MALDI-TOF/TOF21544065
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)34.14< 0.05RNA microarray21752957
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.4< 0.05RNA microarray21752957
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)9.82< 0.05RNA microarray21752957
Exp22723521bHomo sapiens47kidneytubulointerstitialGlomerulonephritis (lupus nephritis)2.740RNA microarray22723521
Exp22723521dHomo sapiens20kidneytubulointerstitialGlomerulonephritis (lupus nephritis)5.220Taqman real-time PCR22723521
Exp23228063Homo sapiens30urinewholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease)1.660.00492LC-MS/MS23228063
Exp24172336Mus musculus6kidneycortexAKI (AKI)2.70.041312596LC-MS/MS24172336

Compile date 08-10-2018© iMODE-CKD consortium