CKDdb-logoCKDdb - Molecule ID A1601

geneC1S
nameComplement C1s component precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
C1S_HUMANP09871ENSG00000182326716Hs.458355120580, 613783

Functions and classifications

GOC:extracellular region, F:calcium ion binding, F:serine-type endopeptidase activity, P:complement activation, classical pathway, P:innate immune response, P:proteolysis, P:proteolysis, C:extracellular region, P:complement activation, P:glial cell differentiation, P:response to cAMP, P:response to cAMP
UniProt3D-structure, Calcium, Complement pathway, Complete proteome, Direct protein sequencing, Disulfide bond, EGF-like domain, Glycoprotein, Hydrolase, Hydroxylation, Immunity, Innate immunity, Metal-binding, Polymorphism, Protease, Reference proteome, Repeat, Serine protease, Signal, Sushi
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp16686758aMus musculus6kidney Transplantation (Allograft Rejection allo. CBA D5)13< 0.01mRNA microarray16686758
Exp16686758bMus musculus6kidney Transplantation (Allograft Rejection iso.CBA D5)3.7< 0.01mRNA microarray16686758
Exp17579666cMus musculus6 to 12kidneywholeremnant_kidney_model (remnant kidney model)2.10.05RNA microarray17579666
Exp19398767Homo sapiens20kidneybiopsy sectionFibrosis (Interstitial fibrosis and tubular atrophy)2.230.000512613RNA microarray19398767
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.230.00361RNA microarray19698090
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)45.97< 0.05RNA microarray21752957
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)2.54< 0.05RNA-seq23757392
Exp23989031aMus musculus kidneycortexGlomerulonephritis (Glomerulonephritis)0.02< 0.01DNA microarray23989031
Exp23989031bMus musculus kidneycortexGlomerulonephritis (Glomerulonephritis)0.04< 0.01DNA microarray23989031
Exp24172336Mus musculus6kidneycortexAKI (AKI)3.460.027318216LC-MS/MS24172336
Exp24761003aRattus norvegicus18kidneymedullaureteral_obstruction (obstructive uropathy)0.38< 0.05LC-MS/MS24761003

Compile date 08-10-2018© iMODE-CKD consortium