CKDdb-logoCKDdb - Molecule ID A1600

geneC1R
nameComplement C1r subcomponent
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
C1R_HUMANP00736ENSG00000159403715Hs.524224216950, 613785

Functions and classifications

GOC:extracellular region, F:calcium ion binding, F:serine-type endopeptidase activity, P:complement activation, classical pathway, P:innate immune response, P:proteolysis, P:complement activation
UniProt3D-structure, Complement pathway, Complete proteome, Direct protein sequencing, Disulfide bond, EGF-like domain, Glycoprotein, Hydrolase, Hydroxylation, Immunity, Innate immunity, Phosphoprotein, Polymorphism, Protease, Reference proteome, Repeat, Serine protease, Signal, Sushi
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17579666cMus musculus6 to 12kidneywholeremnant_kidney_model (remnant kidney model)2.530.05RNA microarray17579666
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.380.00155RNA microarray19698090
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)5.8< 0.05RNA microarray21752957
Exp22266139Homo sapiens kidneyproximal tubule epithelial cellsDiabetes (diabetic nephropathy)0.49.63E-14NGS, RNA-seq.22266139

Compile date 08-10-2018© iMODE-CKD consortium