CKDdb-logoCKDdb - Molecule ID A1598

geneC3, CPAMD1
nameComplement C3 precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
CO3_HUMANP01024ENSG00000125730718Hs.529053120700, 611378, 612925, 613779

Functions and classifications

GOC:extracellular space, C:extracellular vesicular exosome, C:plasma membrane, F:C5L2 anaphylatoxin chemotactic receptor binding, F:endopeptidase inhibitor activity, P:complement activation, alternative pathway, P:complement activation, classical pathway, P:fatty acid metabolic process, P:G-protein coupled receptor signaling pathway, P:inflammatory response, P:negative regulation of endopeptidase activity, P:positive regulation of activation of membrane attack complex, P:positive regulation of angiogenesis, P:positive regulation of G-protein coupled receptor protein signaling pathway, P:positive regulation of glucose transport, P:positive regulation of lipid storage, P:positive regulation of phagocytosis, P:positive regulation of protein phosphorylation, P:positive regulation of type IIa hypersensitivity, P:positive regulation vascular endothelial growth factor production, P:regulation of complement activation, P:regulation of triglyceride biosynthetic process, P:complement activation, C:extracellular region
UniProt3D-structure, Age-related macular degeneration, Cleavage on pair of basic residues, Complement alternate pathway, Complement pathway, Complete proteome, Direct protein sequencing, Disease mutation, Disulfide bond, Fatty acid metabolism, Glycoprotein, Hemolytic uremic syndrome, Immunity, Inflammatory response, Innate immunity, Lipid metabolism, Phosphoprotein, Polymorphism, Reference proteome, Secreted, Signal, Thioester bond
PADBmodulator, regulator

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionValidationPubMed/DOI
Exp17301227Homo sapiens13bloodserumFabry (6 months of ERT) 0.0589nanoLC-ESI-MS/MS 17301227
Exp17579666cMus musculus6 to 12kidneywholeremnant_kidney_model (remnant kidney model)11.10.05RNA microarray 17579666
Exp17579666cMus musculus6 to 12kidneywholeremnant_kidney_model (remnant kidney model)7.980.05RNA microarray 17579666
Exp18187931aMus musculus20kidneyglomeruliGlomerulonephritis (lupus nephritis)4.5< 0.05RNA microarray 18187931
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)3.630.02cDNA microarray 19099603
Exp19698090aHomo sapiens17bloodmononuclear cellsChronic_Renal_Insufficiency (Chronic kidney disease)2.380.0209279RNA microarray 19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)2.570.000484RNA microarray 19698090
Exp20007950aRattus norvegicus8corporawholeDiabetes (Diabetes Mellitus-associated Erectile Dysfunction)1.630.0033MALDI-TOF, LC-MS/MS 20007950
Exp20007950bRattus norvegicus8corporawholeDiabetes (Diabetes Mellitus-associated Erectile Dysfunction)1.910.0033MALDI-TOF, LC-MS/MS 20007950
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy)up MS/MS, LTQ LX linear ion trap 20093355
Exp20181666aMus musculus6kidney IRI (ischemic injury model)10.6< 0.05RNA microarray 20181666
Exp20181666bMus musculus6kidney IRI (ischemic injury model)29.4< 0.05RNA microarray 20181666
Exp20181666cMus musculus6kidney IRI (ischemic injury model)7< 0.05RNA microarray 20181666
Exp20348205aRattus norvegicus10bloodplasmaDiabetes (Gestational Diabetes)0.89< 0.05RP-nano-LC-ESI-MS/MS 20348205
Exp20411046Homo sapiens5kidneycyst fluidPolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease) < 0.001LC-MS/MS 20411046
Exp20411046Homo sapiens5kidneycyst fluidPolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease) < 0.001LC-MS/MS 20411046
Exp20812764Homo sapiens13bloodplasmaTransplantation (Acute Renal Allograft Rejection)4.210.0151LC-MS/MS 20812764
Exp21411733aMus musculus13macrophageF4/80hi cellsGlomerulonephritis (lupus nephritis)2.360cDNA microarray 21411733
Exp21411733bMus musculus11macrophageF4/80hi cellsGlomerulonephritis (lupus nephritis)0.480cDNA microarray 21411733
Exp21544065bRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D)0.770.036MALDI-TOF/TOF 21544065
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)4087.58< 0.05RNA microarray 21752957
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)84.94< 0.05RNA microarray 21752957
Exp22172726Homo sapiens20kidneyglomeruliDiabetes (type 2 diabetic nephropathy)1.760.0001QSTAR Elite LC-MS/MS 22172726
Exp22266139Homo sapiens kidneyproximal tubule epithelial cellsDiabetes (diabetic nephropathy)0.241.58E-69NGS, RNA-seq. 22266139
Exp22970174Mus musculus8kidneywholeChronic_Renal_Insufficiency (mouse_CKD_model)12.3< 0.05RNA microarray 22970174
Exp23143504Homo sapiens urinewholeAKI (AKI)51.270.01LC-MS/MS 23143504
Exp23228063Homo sapiens30urinewholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease)2.450.00003LC-MS/MSMRM23228063
Exp23344851Rattus norvegicus14urineexosomeDiabetes (diabetic nephropathy)3.4 nLC-ESI-UHR-QToF-MS/MS 23344851
Exp23505438bHomo sapiens kidneyproximal tubular cellsDiabetes (diabetic nephropathy)1.60.011cDNA microarray 23505438
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)5.18< 0.05RNA-seq 23757392
Exp24339887Homo sapiens13urinewholeGlomerulonephritis (IgA nephropathy)1.7< 0.05GeLC-MS/MS 24339887
Exp24434790Homo sapiens10kidneyglomeruliGlomerulonephritis (IgA nephropathy)3.41< 0.05MALDI-TOF/TOF 24434790
Exp24497609Rattus norvegicus kidneyglomeruliPuromycin_induced (Puromycin nephropathy model)3.03< 0.05LC-MS/MS 24497609
Exp24761003dRattus norvegicus18kidneymedullaureteral_obstruction (obstructive uropathy)1.93< 0.05LC-MS/MS 24761003
Exp24761003eRattus norvegicus18kidneymedullaureteral_obstruction (obstructive uropathy)0.92< 0.05LC-MS/MS 24761003
Exp24761003fRattus norvegicus18kidneymedullaureteral_obstruction (obstructive uropathy)2.73< 0.05LC-MS/MS 24761003
Exp24798088Rattus norvegicus kidney AKI (AKI)2.490.044MS/MS 24798088
Exp25150443aHomo sapiens24urinesupernatantNephrotic_Syndrome (paediatric idiopathic nephrotic syndrome)2.81.90E-07LC-MS 25150443

Compile date 08-10-2018© iMODE-CKD consortium