CKDdb-logoCKDdb - Molecule ID A1584

geneCOL4A1
nameCollagen alpha 1(IV) chain precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
CO4A1_HUMANP02462ENSG000001874981282Hs.17441120130, 175780, 607595, 611773

Functions and classifications

GOC:collagen type IV, C:endoplasmic reticulum lumen, C:extracellular region, F:extracellular matrix structural constituent, F:platelet-derived growth factor binding, P:angiogenesis, P:axon guidance, P:cellular response to amino acid stimulus, P:collagen catabolic process, P:epithelial cell differentiation, P:extracellular matrix disassembly, P:neuromuscular junction development, C:collagen, P:extracellular matrix organization
UniProt3D-structure, Alternative splicing, Angiogenesis, Basement membrane, Collagen, Complete proteome, Direct protein sequencing, Disease mutation, Disulfide bond, Extracellular matrix, Glycoprotein, Hydroxylation, Polymorphism, Reference proteome, Repeat, Secreted, Signal
PADBCell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17003339aMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)1.49< 0.05cDNA microarray17003339
Exp17003339bMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)2.12< 0.05cDNA microarray17003339
Exp17881425Mus musculus12urinewholeGlomerulonephritis (focal segmental glomerulosclerosis)  MALDI-TOF-MS17881425
Exp18187931aMus musculus20kidneyglomeruliGlomerulonephritis (lupus nephritis)2.4< 0.05RNA microarray18187931
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)2.660.01cDNA microarray19099603
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.470.0114RNA microarray19698090
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)2.897.14E-06RNA microarray20019191
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)4.593.23E-06RNA microarray20019191
Exp20812764Homo sapiens13bloodplasmaTransplantation (Acute Renal Allograft Rejection)0.390.2545LC-MS/MS20812764
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)21.1< 0.05RNA microarray21752957
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)9.07< 0.05RNA microarray21752957
Exp22172726Homo sapiens20kidneyglomeruliDiabetes (type 2 diabetic nephropathy)1.750.0001QSTAR Elite LC-MS/MS22172726
Exp23326503Rattus norvegicus kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease)2.060.00000616mRNA microarray23326503
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)2.21< 0.05RNA-seq23757392
Exp24172336Mus musculus6kidneycortexAKI (AKI)4.720.003196058LC-MS/MS24172336
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)2.10.0000469RNA microarray24569379
Exp25769567Homo sapiens19kidneygraftsChronic_rejection (Chronic_rejection)2.07< 0.05ESI-TOF/TOF25769567
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.421.28E-03RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium