CKDdb-logoCKDdb - Molecule ID A1563

geneNpnt
nameNephronectin
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
NPNT_MOUSEQ91V88ENSMUSG00000040998114249Mm.279310610306

Functions and classifications

GOC:basement membrane, C:extracellular matrix, C:extracellular region, C:membrane, C:proteinaceous extracellular matrix, C:smooth muscle contractile fiber, F:calcium ion binding, F:integrin binding, P:branching involved in ureteric bud morphogenesis, P:cell-cell adhesion mediated by integrin, P:cell-matrix adhesion, P:cellular response to tumor necrosis factor, P:establishment of protein localization, P:extracellular matrix organization, P:pilomotor reflex, P:positive regulation of alkaline phosphatase activity, P:positive regulation of cell-substrate adhesion, P:positive regulation of ERK1 and ERK2 cascade, P:positive regulation of osteoblast differentiation, P:positive regulation of smooth muscle contraction, P:positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation, P:positive regulation of transforming growth factor beta receptor signaling pathway, P:ureteric bud development
UniProtAlternative splicing, Calcium, Cell adhesion, Complete proteome, Developmental protein, Differentiation, Disulfide bond, EGF-like domain, Extracellular matrix, Reference proteome, Repeat, Secreted, Signal
PADBCell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17003339aMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)1.82< 0.05cDNA microarray17003339
Exp17003339bMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)2.58< 0.05cDNA microarray17003339
Exp22172726Homo sapiens20kidneyglomeruliDiabetes (type 2 diabetic nephropathy)1.250.0006QSTAR Elite LC-MS/MS22172726

Compile date 08-10-2018© iMODE-CKD consortium