CKDdb-logoCKDdb - Molecule ID A1557

geneEFNB2, EPLG5, HTKL
nameEphrin-B2 precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
EFNB2_HUMANP52799ENSG000001252661948Hs.149239600527

Functions and classifications

GOC:integral component of plasma membrane, F:ephrin receptor binding, P:cell adhesion, P:cell differentiation, P:cell migration involved in sprouting angiogenesis, P:cell-cell signaling, P:ephrin receptor signaling pathway, P:lymph vessel development, P:negative regulation of keratinocyte proliferation, P:nervous system development, P:organ morphogenesis, P:positive regulation of cardiac muscle cell differentiation, P:regulation of chemotaxis, P:viral process, C:plasma membrane, P:blood vessel morphogenesis, C:integral to plasma membrane, P:Notch signaling pathway, P:virus-host interaction
UniProt3D-structure, Angiogenesis, Complete proteome, Developmental protein, Differentiation, Disulfide bond, Glycoprotein, Host-virus interaction, Membrane, Neurogenesis, Phosphoprotein, Reference proteome, Signal, Transmembrane, Transmembrane helix
PADBdevelopment, cell growth, differentiation, morphogenesis

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionValidationPubMed/DOI
Exp17003339aMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)2.11< 0.05cDNA microarrayRT-PCR17003339
Exp17003339bMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)1.63< 0.05cDNA microarrayRT-PCR17003339
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.290.00767RNA microarray 19698090
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)4.033.23E-06RNA microarray 20019191
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)5.76< 0.05RNA microarray 21752957
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)5.84< 0.05RNA microarray 21752957
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.15< 0.05RNA microarray 21752957
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.220.013999RNA microarray 26317775

Compile date 08-10-2018© iMODE-CKD consortium