CKDdb-logoCKDdb - Molecule ID A1554

geneACHE, ARACHE
nameAcetylcholinesterase precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ACES_HUMANP22303ENSG0000008708543Hs.154495100740, 112100

Functions and classifications

GOC:anchored component of membrane, C:axon, C:basal lamina, C:cell junction, C:cell surface, C:dendrite, C:endoplasmic reticulum lumen, C:extracellular space, C:Golgi apparatus, C:neuromuscular junction, C:nucleus, C:perinuclear region of cytoplasm, C:postsynaptic membrane, C:presynaptic membrane, F:acetylcholine binding, F:acetylcholinesterase activity, F:beta-amyloid binding, F:collagen binding, F:laminin binding, F:protein homodimerization activity, F:serine hydrolase activity, P:acetylcholine catabolic process in synaptic cleft, P:amyloid precursor protein metabolic process, P:cell adhesion, P:cell proliferation, P:choline metabolic process, P:DNA replication, P:muscle organ development, P:negative regulation of synaptic transmission, cholinergic, P:neurotransmitter biosynthetic process, P:neurotransmitter receptor biosynthetic process, P:osteoblast development, P:phosphatidylcholine biosynthetic process, P:positive regulation of protein secretion, P:protein tetramerization, P:receptor internalization, P:regulation of axonogenesis, P:regulation of dendrite morphogenesis, P:regulation of receptor recycling, P:response to wounding, P:retina development in camera-type eye, P:synapse assembly, F:cholinesterase activity, P:metabolic process, C:plasma membrane, P:acetylcholine catabolic process, C:anchored to membrane, C:synaptic cleft, F:carboxylesterase activity, C:membrane
UniProt3D-structure, Alternative splicing, Blood group antigen, Cell junction, Cell membrane, Complete proteome, Direct protein sequencing, Disulfide bond, Glycoprotein, GPI-anchor, Hydrolase, Lipoprotein, Membrane, Neurotransmitter degradation, Nucleus, Polymorphism, Reference proteome, Secreted, Serine esterase, Signal, Synapse
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseBiomarkerFold change in diseaseP-valueDetectionMol. modificationValidationPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis) 0.280.00141RNA microarray  19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis) 0.340.0116RNA microarray  19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis) 0.440.0431RNA microarray  19698090

Compile date 08-30-2016© iMODE-CKD consortium