CKDdb-logoCKDdb - Molecule ID A1552

geneAPOA1, A175P
nameApolipoprotein A-I precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
APOA1_HUMANP02647ENSG00000118137335Hs.93194105200, 107680, 205400, 604091

Functions and classifications

GOC:cytosol, C:early endosome, C:endocytic vesicle lumen, C:endoplasmic reticulum lumen, C:nucleus, C:plasma membrane, C:secretory granule lumen, C:spherical high-density lipoprotein particle, C:very-low-density lipoprotein particle, F:beta-amyloid binding, F:cholesterol binding, F:cholesterol transporter activity, F:high-density lipoprotein particle binding, F:lipase inhibitor activity, F:phosphatidylcholine-sterol O-acyltransferase activator activity, F:phospholipid binding, F:phospholipid transporter activity, P:adrenal gland development, P:blood vessel endothelial cell migration, P:cholesterol biosynthetic process, P:cholesterol efflux, P:cholesterol homeostasis, P:cholesterol import, P:cholesterol metabolic process, P:endothelial cell proliferation, P:G-protein coupled receptor signaling pathway, P:glucocorticoid metabolic process, P:high-density lipoprotein particle assembly, P:high-density lipoprotein particle clearance, P:high-density lipoprotein particle remodeling, P:lipid storage, P:lipoprotein biosynthetic process, P:lipoprotein metabolic process, P:negative regulation of cell adhesion molecule production, P:negative regulation of cytokine secretion involved in immune response, P:negative regulation of heterotypic cell-cell adhesion, P:negative regulation of inflammatory response, P:negative regulation of interleukin-1 beta secretion, P:negative regulation of lipase activity, P:negative regulation of tumor necrosis factor-mediated signaling pathway, P:negative regulation of very-low-density lipoprotein particle remodeling, P:organ regeneration, P:peptidyl-methionine modification, P:peripheral nervous system axon regeneration, P:phosphatidylcholine biosynthetic process, P:phospholipid efflux, P:phospholipid homeostasis, P:phototransduction, visible light, P:platelet activation, P:platelet degranulation, P:positive regulation of cholesterol esterification, P:positive regulation of hydrolase activity, P:positive regulation of transferase activity, P:protein oxidation, P:protein stabilization, P:regulation of Cdc42 protein signal transduction, P:regulation of intestinal cholesterol absorption, P:regulation of protein phosphorylation, P:response to drug, P:response to estrogen, P:response to nutrient, P:retinoid metabolic process, P:reverse cholesterol transport, P:triglyceride homeostasis, C:extracellular region, F:lipid binding, P:lipid transport, C:endocytic vesicle, C:secretory granule, P:negative regulation of hydrolase activity, P:triglyceride homeostasis
UniProt3D-structure, Amyloid, Amyloidosis, Atherosclerosis, Cholesterol metabolism, Complete proteome, Direct protein sequencing, Disease mutation, Glycation, Glycoprotein, HDL, Lipid metabolism, Lipid transport, Lipoprotein, Neuropathy, Oxidation, Palmitate, Phosphoprotein, Polymorphism, Reference proteome, Repeat, Secreted, Signal, Steroid metabolism, Sterol metabolism, Transport
PADBtransport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseBiomarkerFold change in diseaseP-valueDetectionValidationPubMed/DOI
Exp17301227Homo sapiens13bloodserumFabry (6 months of ERT)  0.6355nanoLC-ESI-MS/MS 17301227
Exp17327332aHomo sapiens42urinewholeDiabetes (Diabetic Nephropathy) 0.31< 0.05LC-MS/MS 17327332
Exp17327332bHomo sapiens42urinewholeDiabetes (Diabetic Nephropathy) 0.4< 0.05LC-MS/MS 17327332
Exp17579666cMus musculus6 to 12kidneywholeremnant_kidney_model (remnant kidney model) 59.420.05RNA microarraysqRT-PCR17579666
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis) 0.280.000927RNA microarray 19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis) 0.380.00287RNA microarray 19698090
Exp20007950aRattus norvegicus8corporawholeDiabetes (Diabetes Mellitus-associated Erectile Dysfunction) 2.890.00013MALDI-TOF, LC-MS/MS 20007950
Exp20007950bRattus norvegicus8corporawholeDiabetes (Diabetes Mellitus-associated Erectile Dysfunction) 3.390.00013MALDI-TOF, LC-MS/MS 20007950
Exp20348205aRattus norvegicus10bloodplasmaDiabetes (Gestational Diabetes) 1.17< 0.05RP-nano-LC-ESI-MS/MS 20348205
Exp20812764Homo sapiens13bloodplasmaTransplantation (Acute Renal Allograft Rejection) 0.330.0872LC-MS/MS 20812764
Exp21354196Mus musculus24urinewholeCyclosporine_A_induced (cyclosporine A nephrotoxicity) 3.69 MS/MS 21354196
Exp21544065aRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D) 1.46< 0.001MALDI-TOF/TOF 21544065
Exp21544065bRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D) 3.49< 0.001MALDI-TOF/TOF 21544065
Exp21544065cRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D) 2.72< 0.001MALDI-TOF/TOF 21544065
Exp23078846Homo sapiens12kidneyperitoneal dialysateDialysis (Peritonitis) down< 0.05RP-nano-HPLC-ESI-MS/MSwestern blot, ELISA23078846
Exp23143504Homo sapiens urinewholeAKI (AKI) 369.650.04LC-MS/MS 23143504
Exp23205849Homo sapiens40bloodplasmaGlomerulonephritis (FSGS)ApoA-Ib detected in relapsing FSGS patients  MALDI-TOF 23205849
Exp23228063Homo sapiens30urinewholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease) 3.890.00003LC-MS/MS 23228063
Exp23344851Rattus norvegicus14urineexosomeDiabetes (diabetic nephropathy) 4.21 nLC-ESI-UHR-QToF-MS/MS 23344851
Exp23762862Homo sapiens10kidneyperitoneal dialysateGlomerulonephritis (chronic glomerulonephritis) 23.67 +/- 2.89< 0.05LC-MS/MS 23762862
Exp24339887Homo sapiens13urinewholeGlomerulonephritis (IgA nephropathy) 5.8< 0.05GeLC-MS/MS 24339887
Exp24497609Rattus norvegicus kidneyglomeruliPuromycin_induced (Puromycin nephropathy model) 2.83< 0.05LC-MS/MS 24497609
Exp24790760Homo sapiens19urinewholeGlomerulonephritis (focal segmental glomerulosclerosis) 5.64 nLC-MS/MS 24790760
Exp24927646aMus musculus16kidney Diabetes (diabetic nephropathy treated with Phlorizin) 1.85< 0.05LC-MS/MS 24927646
Exp24927646bMus musculus16kidney Diabetes (diabetic nephropathy) 2.9< 0.05LC-MS/MS 24927646
Exp25150443aHomo sapiens24urinesupernatantNephrotic_Syndrome (paediatric idiopathic nephrotic syndrome) 3.36.00E-06LC-MS 25150443
Exp25666440Homo sapiens23urinesupernatantFabry (naive Fabry patients) 0.50.012096nanoLC-ESI-MS/MS 25666440

Compile date 08-10-2018© iMODE-CKD consortium