CKDdb-logoCKDdb - Molecule ID A1526

geneSPP1, BNSP, OPN
nameOsteopontin precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
OSTP_HUMANP10451ENSG000001187856696Hs.313166490

Functions and classifications

GOC:apical part of cell, C:cell projection, C:extracellular space, C:membrane-bounded vesicle, C:perinuclear region of cytoplasm, F:extracellular matrix binding, P:biomineral tissue development, P:cell adhesion, P:decidualization, P:embryo implantation, P:extracellular matrix organization, P:inflammatory response, P:negative regulation of collateral sprouting of intact axon in response to injury, P:neutrophil chemotaxis, P:osteoblast differentiation, P:positive regulation of bone resorption, P:positive regulation of cell-substrate adhesion, P:response to steroid hormone, P:response to vitamin D, P:ossification, P:response to steroid hormone stimulus
UniProt3D-structure, Alternative splicing, Biomineralization, Cell adhesion, Complete proteome, Cytokine, Direct protein sequencing, Glycoprotein, Phosphoprotein, Polymorphism, Reference proteome, Secreted, Sialic acid, Signal
PADBCell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17003339aMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)1.73< 0.05cDNA microarray17003339
Exp17003339bMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)2.93< 0.05cDNA microarray17003339
Exp17579666cMus musculus6 to 12kidneywholeremnant_kidney_model (remnant kidney model)4.380.05RNA microarray17579666
Exp19070598aMus musculus36kidneywholeDiabetes (diabetic nephropathy)2.35< 0.05cDNA microarray19070598
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)2.270.03cDNA microarray19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)2.790.02cDNA microarray19099603
Exp19346236Homo sapiens10kidneycystsPolycystic_Kidney_Disease (Autosomal dominant polycystic kidney disease)0.110.005mRNA microarray19346236
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.130.000139RNA microarray19698090
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.440.000113537RNA microarray20019191
Exp20543976Homo sapiens40urinewholeTransplantation (acute renal allograft rejection)0.2 LC-MS/MS20543976
Exp20543976Homo sapiens40urinewholeTransplantation (acute renal allograft rejection)0.2 LC-MS/MS20543976
Exp20543976Homo sapiens40urinewholeTransplantation (acute renal allograft rejection)0.2 LC-MS/MS20543976
Exp20543976Homo sapiens40urinewholeTransplantation (acute renal allograft rejection)0.2 LC-MS/MS20543976
Exp20639044bHomo sapiens46urinewholeureteral_obstruction (unilateral uteropelvic junction obstruction)1.65< 0.05LC-MS/MS20639044
Exp20813037bRattus norvegicus6kidneywholePolycystic_Kidney_Disease (polycystic kidney disease)2.822.26E-13RNA microarray20813037
Exp20813037cRattus norvegicus6kidneywholePolycystic_Kidney_Disease (polycystic kidney disease)3.043.33E-14RNA microarray20813037
Exp20847290Homo sapiens30kidneyglomeruliGlomerulonephritis (FSGS + COLL)4.520.0863RNA microarray20847290
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)4.14< 0.05RNA microarray21752957
Exp21854746aHomo sapiens35kidneyglomeruliGlomerulonephritis (membranous nephropathy)0.6 RNA microarray21854746
Exp21854746bHomo sapiens23kidneyglomeruliLipoid_Nephrosis (minimal change disease)0.6 RNA microarray21854746
Exp21854746CHomo sapiens27kidneyglomeruliGlomerulonephritis (focal segmental glomerulosclerosis)  RNA microarray21854746
Exp21854746dHomo sapiens28kidneyglomeruliGlomerulonephritis (focal segmental glomerulosclerosis)0.7 RNA microarray21854746
Exp22536212Homo sapiens86urinewholeDiabetes (type 2 diabetic nephropathy)0.570hybrid quadrupole-TOF, LC-MS/MS22536212
Exp22536212Homo sapiens86urinewholeDiabetes (type 2 diabetic nephropathy)0.580hybrid quadrupole-TOF, LC-MS/MS22536212
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity)6.040.000023RNA microarray23291264
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity)6.590.000885RNA microarray23291264
Exp23326503Rattus norvegicus kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease)3.389.74E-08mRNA microarray23326503
Exp23464927Homo sapiens10urine Fabry (12 months of ERT)1.32<0.05QTOF MS/MS23464927
Exp23757392bRattus norvegicus13kidneywholeDiabetes (diabetic nephropathy)4.46< 0.05RNA-seq23757392
Exp24096133fHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy and nephropathy vs type 1 diabetes with retinopathy)0.38 1DE, MALDI24096133
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)5.250.00000853RNA microarray24569379
Exp25150443aHomo sapiens24urinesupernatantNephrotic_Syndrome (paediatric idiopathic nephrotic syndrome)2.61.50E-08LC-MS25150443

Compile date 08-10-2018© iMODE-CKD consortium