CKDdb-logoCKDdb - Molecule ID A1503

genePROC, PROC1
nameVitamin-K-dependent protein C precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
PROC_HUMANP04070ENSG000001157185624Hs.224698176860, 612283, 612304

Functions and classifications

GOC:endoplasmic reticulum lumen, C:extracellular region, C:Golgi lumen, C:plasma membrane, F:calcium ion binding, F:serine-type endopeptidase activity, P:blood coagulation, P:leukocyte migration, P:negative regulation of apoptotic process, P:negative regulation of blood coagulation, P:peptidyl-glutamic acid carboxylation, P:post-translational protein modification, P:proteolysis, F:peptidase activity, P:metabolic process, C:extracellular space, F:hydrolase activity
UniProt3D-structure, Blood coagulation, Calcium, Cleavage on pair of basic residues, Complete proteome, Direct protein sequencing, Disease mutation, Disulfide bond, EGF-like domain, Gamma-carboxyglutamic acid, Glycoprotein, Hemostasis, Hydrolase, Hydroxylation, Polymorphism, Protease, Reference proteome, Repeat, Serine protease, Signal, Thrombophilia, Zymogen
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17003339aMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)0.46< 0.05cDNA microarray17003339
Exp17003339bMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)0.4< 0.05cDNA microarray17003339
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.210.0000427RNA microarray19698090
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.15< 0.05RNA microarray21752957
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity)0.250.000656RNA microarray23291264
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity)0.260.0048RNA microarray23291264
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)0.36< 0.05RNA-seq23757392
Exp23757392bRattus norvegicus13kidneywholeDiabetes (diabetic nephropathy)0.47< 0.05RNA-seq23757392

Compile date 08-10-2018© iMODE-CKD consortium