CKDdb-logoCKDdb - Molecule ID A1497

geneATF, PLAU
nameUrokinase-type plasminogen activator precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
UROK_HUMANP00749ENSG000001228615328Hs.77274191840, 601709

Functions and classifications

GOC:cell surface, C:extracellular space, C:plasma membrane, F:serine-type endopeptidase activity, P:blood coagulation, P:chemotaxis, P:fibrinolysis, P:proteolysis, P:regulation of cell adhesion mediated by integrin, P:regulation of cell proliferation, P:regulation of receptor activity, P:regulation of smooth muscle cell migration, P:regulation of smooth muscle cell-matrix adhesion, P:response to hypoxia, P:signal transduction, P:smooth muscle cell migration, F:kinase activity, P:angiogenesis, P:embryo implantation, P:response to hyperoxia, P:skeletal muscle tissue regeneration
UniProt3D-structure, Alternative splicing, Blood coagulation, Complete proteome, Direct protein sequencing, Disulfide bond, EGF-like domain, Fibrinolysis, Glycoprotein, Hemostasis, Hydrolase, Kringle, Pharmaceutical, Phosphoprotein, Plasminogen activation, Polymorphism, Protease, Reference proteome, Secreted, Serine protease, Signal, Zymogen, Kinase, Transferase
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19398767Homo sapiens20kidneybiopsy sectionFibrosis (Interstitial fibrosis and tubular atrophy)0.460.000932369RNA microarray19398767
Exp20543976Homo sapiens40urinewholeTransplantation (acute renal allograft rejection)0.1 LC-MS/MS20543976
Exp20543976Homo sapiens40urinewholeTransplantation (acute renal allograft rejection)0.1 LC-MS/MS20543976
Exp22266139Homo sapiens kidneyproximal tubule epithelial cellsDiabetes (diabetic nephropathy)0.419.36E-42NGS, RNA-seq.22266139
Exp22536212Homo sapiens86urinewholeDiabetes (type 2 diabetic nephropathy)0.390.01hybrid quadrupole-TOF, LC-MS/MS22536212
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity)0.230.00175RNA microarray23291264
Exp23291264bRattus norvegicus kidneyproximal tubulecisplatin_induced (cisplatin-induced nephrotoxicity)0.390.00569RNA microarray23291264
Exp23506792aMus musculus10urinewholeDiclofenac_induced (diclofenac-induced renal injury) < 0.05MALDI-TOF MS23506792
Exp24172336Mus musculus6kidneycortexAKI (AKI)1.060.045324529LC-MS/MS24172336
Exp25150443aHomo sapiens24urinesupernatantNephrotic_Syndrome (paediatric idiopathic nephrotic syndrome)3.53.50E-03LC-MS25150443

Compile date 08-10-2018© iMODE-CKD consortium