CKDdb-logoCKDdb - Molecule ID A1466

geneFN1, FN
nameFibronectin
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
FINC_HUMANP02751ENSG000001154142335Hs.203717135600, 601894

Functions and classifications

GOC:apical plasma membrane, C:basement membrane, C:endoplasmic reticulum-Golgi intermediate compartment, C:fibrinogen complex, C:platelet alpha granule lumen, C:proteinaceous extracellular matrix, F:collagen binding, F:extracellular matrix structural constituent, F:heparin binding, F:peptidase activator activity, P:acute-phase response, P:angiogenesis, P:calcium-independent cell-matrix adhesion, P:cell-substrate junction assembly, P:extracellular matrix organization, P:leukocyte migration, P:peptide cross-linking, P:platelet activation, P:platelet degranulation, P:regulation of cell shape, P:substrate adhesion-dependent cell spreading, C:extracellular region, P:wound healing, F:mercury ion binding
UniProt3D-structure, Acute phase, Alternative splicing, Angiogenesis, Cell adhesion, Cell shape, Complete proteome, Direct protein sequencing, Disease mutation, Disulfide bond, Extracellular matrix, Glycoprotein, Heparin-binding, Isopeptide bond, Phosphoprotein, Polymorphism, Pyrrolidone carboxylic acid, Reference proteome, Repeat, Secreted, Signal, Sulfation
PADBCell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17183245Homo sapiens24kidneyproximal tubuleproteinuria (proteinuric nephropathies)0.18< 0.05cDNA microarrays17183245
Exp17579666cMus musculus6 to 12kidneywholeremnant_kidney_model (remnant kidney model)3.280.05RNA microarray17579666
Exp18187931aMus musculus20kidneyglomeruliGlomerulonephritis (lupus nephritis)4.6< 0.05RNA microarray18187931
Exp18440303Rattus norvegicus20urineglycoproteinsGlomerulonephritis (adriamycin nephropathy and Thy1.1 induced glomerulonephritis)1.5 LC-MS/MS18440303
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)2.170.02cDNA microarray19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)3.760.01cDNA microarray19099603
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.390.00207RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.480.0246RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.480.0256RNA microarray19698090
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)5.53.23E-06RNA microarray20019191
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)5.623.23E-06RNA microarray20019191
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)6.283.23E-06RNA microarray20019191
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)6.873.23E-06RNA microarray20019191
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy)up MS/MS, LTQ LX linear ion trap20093355
Exp20543976Homo sapiens40urinewholeTransplantation (acute renal allograft rejection)0.3 LC-MS/MS20543976
Exp20639044aHomo sapiens46urinewholeureteral_obstruction (unilateral uteropelvic junction obstruction)1.33< 0.05LC-MS/MS20639044
Exp20639044bHomo sapiens46urinewholeureteral_obstruction (unilateral uteropelvic junction obstruction)1.34< 0.05LC-MS/MS20639044
Exp20812764Homo sapiens13bloodplasmaTransplantation (Acute Renal Allograft Rejection)7.110.0014LC-MS/MS20812764
Exp21544065aRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D)1.450.045MALDI-TOF/TOF21544065
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)20.04< 0.05RNA microarray21752957
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)20.87< 0.05RNA microarray21752957
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)38.31< 0.05RNA microarray21752957
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)41.1< 0.05RNA microarray21752957
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)7.02< 0.05RNA microarray21752957
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)7.51< 0.05RNA microarray21752957
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)8.72< 0.05RNA microarray21752957
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)9< 0.05RNA microarray21752957
Exp22172726Homo sapiens20kidneyglomeruliDiabetes (type 2 diabetic nephropathy)1.430.0001QSTAR Elite LC-MS/MS22172726
Exp22536212Homo sapiens86urinewholeDiabetes (type 2 diabetic nephropathy)1.270.01hybrid quadrupole-TOF, LC-MS/MS22536212
Exp23228063Homo sapiens30urinewholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease)0.80.01028LC-MS/MS23228063
Exp23326503Rattus norvegicus kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease)2.190.0000137mRNA microarray23326503
Exp23344851Rattus norvegicus14urineexosomeDiabetes (diabetic nephropathy)9.74 nLC-ESI-UHR-QToF-MS/MS23344851
Exp23464927Homo sapiens10urine Fabry (12 months of ERT)1.96<0.05QTOF MS/MS23464927
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)3.27< 0.05RNA-seq23757392
Exp24096133bHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy)1000 1DE, MALDI24096133
Exp24096133dHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy vs type 1 diabetes without retinopathy or nephropathy)1000 1DE, MALDI24096133
Exp24096133fHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy and nephropathy vs type 1 diabetes with retinopathy)0 1DE, MALDI24096133
Exp24172336Mus musculus6kidneycortexAKI (AKI)1.960.02133305LC-MS/MS24172336
Exp24172336Mus musculus6kidneycortexAKI (AKI)20.013755561LC-MS/MS24172336

Compile date 08-10-2018© iMODE-CKD consortium