CKDdb-logoCKDdb - Molecule ID A1397

geneBrca2
nameBreast cancer type 2 susceptibility protein homolog
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
BRCA2_MOUSEP97929ENSMUSG0000004114712190Mm.236256114480, 227650, 600185, 605724, 612555, 613029, 613347, 155720

Functions and classifications

GOC:BRCA2-MAGE-D1 complex, C:centrosome, C:cytoplasm, C:nucleoplasm, C:nucleus, C:secretory granule, F:gamma-tubulin binding, F:H3 histone acetyltransferase activity, F:H4 histone acetyltransferase activity, F:protein binding, F:single-stranded DNA binding, P:brain development, P:cell aging, P:cell proliferation, P:cellular response to DNA damage stimulus, P:centrosome duplication, P:chordate embryonic development, P:chromosome organization, P:cytokinesis, P:DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, P:double-strand break repair, P:double-strand break repair via homologous recombination, P:female gonad development, P:hemopoiesis, P:inner cell mass cell proliferation, P:intrinsic apoptotic signaling pathway in response to DNA damage, P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, P:male meiosis I, P:negative regulation of mammary gland epithelial cell proliferation, P:nucleotide-excision repair, P:oocyte maturation, P:positive regulation of mitotic cell cycle, P:positive regulation of transcription, DNA-templated, P:regulation of cell proliferation, P:regulation of cytokinesis, P:replication fork protection, P:response to gamma radiation, P:response to UV-C, P:response to X-ray, P:spermatogenesis, P:regulation of S phase of mitotic cell cycle
UniProt3D-structure, Cell cycle, Complete proteome, Cytoplasm, Cytoskeleton, Direct protein sequencing, DNA damage, DNA recombination, DNA repair, DNA-binding, Nucleus, Phosphoprotein, Polymorphism, Reference proteome, Repeat, Tumor suppressor, Ubl conjugation
PADBCell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp15042541Homo sapiens4kidneyglomeruliDiabetes (diabetic nephropathy)0.13< 0.01RNA microarray15042541
Exp17579666aMus musculus6 to 12kidneywholeremnant_kidney_model (remnant kidney model)0.330.05RNA microarray17579666
Exp21659735Homo sapiens kidneymesangial cellsDiabetes (diabetic nephropathy)1.65 MALDI-TOF-MS21659735
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)2.24< 0.05RNA-seq23757392
Exp23757392bRattus norvegicus13kidneywholeDiabetes (diabetic nephropathy)2.08< 0.05RNA-seq23757392
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.351.66E-03RNA microarray26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.160.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium