CKDdb-logoCKDdb - Molecule ID A138C

geneABCC6, ara, URG7
nameMultidrug resistance-associated protein 6
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
MRP6_HUMANO95255ENSG00000091262368Hs.442182264800, 603234, 614473, 177850

Functions and classifications

GOC:apical plasma membrane, C:basolateral plasma membrane, C:integral component of membrane, C:lateral plasma membrane, C:plasma membrane, F:ATP binding, F:ATPase activity, coupled to transmembrane movement of substances, P:response to drug, P:visual perception, C:integral component of membrane, P:ATP catabolic process, F:ATPase activity, coupled to transmembrane movement of substances, C:integral to membrane, C:integral to membrane
UniProtAlternative splicing, ATP-binding, Cell membrane, Complete proteome, Disease mutation, Glycoprotein, Membrane, Nucleotide-binding, Polymorphism, Reference proteome, Repeat, Sensory transduction, Transmembrane, Transmembrane helix, Transport, Vision, Cyclin, Phosphoprotein
PADBcell cycle (turnover, mitosis, meiosis)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090aHomo sapiens17bloodmononuclear cellsChronic_Renal_Insufficiency (Chronic kidney disease)2.230.0277236RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.440.00122RNA microarray19698090
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.382.62E-05RNA microarray20019191
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.434.60E-05RNA microarray20019191
Exp25770168Homo sapiens17bloodmononuclear cellsGlomerulonephritis (IgA nephropathy)4.920.001RNA microarray25770168
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)23.910.006293RNA microarray26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)7.840.004477RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium