CKDdb-logoCKDdb - Molecule ID A1363

geneADCY8
nameAdenylate cyclase, type VIII
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ADCY8_HUMANP40145ENSP00000286355114Hs.591859103070

Functions and classifications

GOC:integral component of membrane, C:plasma membrane, F:ATP binding, F:calcium- and calmodulin-responsive adenylate cyclase activity, F:metal ion binding, P:activation of phospholipase C activity, P:activation of protein kinase A activity, P:adenylate cyclase-activating G-protein coupled receptor signaling pathway, P:adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway, P:cellular response to glucagon stimulus, P:energy reserve metabolic process, P:epidermal growth factor receptor signaling pathway, P:fibroblast growth factor receptor signaling pathway, P:innate immune response, P:intracellular signal transduction, P:learning or memory, P:long-term memory, P:neurotrophin TRK receptor signaling pathway, P:synaptic transmission, P:transmembrane transport, P:water transport, F:adenylate cyclase activity, F:nucleotide binding, P:cAMP biosynthetic process, C:integral to membrane, C:intracellular, P:cAMP-mediated signaling, P:nerve growth factor receptor signaling pathway
UniProtATP-binding, cAMP biosynthesis, Complete proteome, Glycoprotein, Lyase, Magnesium, Membrane, Metal-binding, Nucleotide-binding, Polymorphism, Reference proteome, Repeat, Transmembrane, Transmembrane helix
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.35< 0.05RNA microarray21752957
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.38.59E-04RNA microarray26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.170.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium