CKDdb-logoCKDdb - Molecule ID A1356

geneADCY1
nameAdenylate cyclase
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ADCY1_HUMANQ08828ENSG00000164742107Hs.192215103072

Functions and classifications

GOC:integral component of membrane, C:nucleus, C:plasma membrane, F:ATP binding, F:calcium- and calmodulin-responsive adenylate cyclase activity, F:calmodulin binding, F:metal ion binding, P:activation of phospholipase C activity, P:activation of protein kinase A activity, P:adenylate cyclase-activating G-protein coupled receptor signaling pathway, P:adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway, P:axonogenesis, P:cellular response to glucagon stimulus, P:circadian rhythm, P:energy reserve metabolic process, P:epidermal growth factor receptor signaling pathway, P:fibroblast growth factor receptor signaling pathway, P:innate immune response, P:intracellular signal transduction, P:long-term memory, P:neurotrophin TRK receptor signaling pathway, P:response to drug, P:response to lithium ion, P:synaptic transmission, P:transmembrane transport, P:water transport, F:nucleotide binding, F:phosphorus-oxygen lyase activity, P:cyclic nucleotide biosynthetic process, C:integral to membrane, P:nerve growth factor receptor signaling pathway, C:intracellular
UniProtATP-binding, Calmodulin-binding, cAMP biosynthesis, Complete proteome, Glycoprotein, Lyase, Magnesium, Membrane, Metal-binding, Nucleotide-binding, Polymorphism, Reference proteome, Repeat, Transmembrane, Transmembrane helix
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17183245Homo sapiens24kidneyproximal tubuleproteinuria (proteinuric nephropathies)0.32< 0.05cDNA microarrays17183245
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.180.00000418RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.330.0118RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.360.0026RNA microarray19698090
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)3.258.81E-05RNA microarray20019191
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)0.47< 0.05RNA-seq23757392
Exp23935909Homo sapiens24bloodmonocytesChronic_Renal_Insufficiency (Chronic kidney disease)6.590.0050167RNA microarray23935909
Exp24172336Mus musculus6kidneycortexAKI (AKI)10000.0062007LC-MS/MS24172336
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.244.29E-04RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium