CKDdb-logoCKDdb - Molecule ID A1318

geneAtm
nameSerine-protein kinase ATM
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ATM_MOUSEQ62388ENSMUSG0000003421811920Mm.5088208900, 607585

Functions and classifications

GOC:chromosome, telomeric region, C:cytoplasmic membrane-bounded vesicle, C:nucleoplasm, C:nucleus, C:spindle, F:1-phosphatidylinositol-3-kinase activity, F:ATP binding, F:DNA binding, F:DNA-dependent protein kinase activity, F:histone serine kinase activity, F:protein binding, F:protein kinase activity, F:protein N-terminus binding, F:protein serine/threonine kinase activity, P:brain development, P:cell cycle arrest, P:cellular response to DNA damage stimulus, P:cellular response to gamma radiation, P:DNA damage checkpoint, P:DNA damage induced protein phosphorylation, P:DNA repair, P:female gamete generation, P:heart development, P:histone mRNA catabolic process, P:intrinsic apoptotic signaling pathway in response to DNA damage, P:lipoprotein catabolic process, P:mitotic spindle assembly checkpoint, P:negative regulation of B cell proliferation, P:neuron apoptotic process, P:oocyte development, P:positive regulation of DNA damage response, signal transduction by p53 class mediator, P:positive regulation of neuron apoptotic process, P:pre-B cell allelic exclusion, P:protein autophosphorylation, P:protein phosphorylation, P:response to hypoxia, P:response to ionizing radiation, P:signal transduction involved in mitotic G2 DNA damage checkpoint, P:somitogenesis, C:nucleus, C:spindle, F:protein kinase activity, P:brain development, P:cellular response to DNA damage stimulus, P:DNA damage checkpoint, P:DNA repair, P:female gamete generation, P:heart development, P:intrinsic apoptotic signaling pathway in response to DNA damage, P:lipoprotein catabolic process, P:neuron apoptotic process, P:oocyte development, P:positive regulation of neuron apoptotic process, P:protein phosphorylation, P:response to ionizing radiation, P:somitogenesis, C:nucleus, C:spindle, F:protein kinase activity, F:protein serine/threonine kinase activity, P:brain development, P:cellular response to DNA damage stimulus, P:DNA damage checkpoint, P:DNA repair, P:female gamete generation, P:heart development, P:intrinsic apoptotic signaling pathway in response to DNA damage, P:lipoprotein catabolic process, P:neuron apoptotic process, P:oocyte development, P:positive regulation of neuron apoptotic process, P:protein phosphorylation, P:response to ionizing radiation, P:somitogenesis, C:chromosome, telomeric region, C:cytoplasm, C:nucleus, C:spindle, F:1-phosphatidylinositol-3-kinase activity, F:ATP binding, F:DNA-dependent protein kinase activity, F:histone serine kinase activity, F:protein kinase activity, P:brain development, P:cell cycle arrest, P:cellular response to DNA damage stimulus, P:cellular response to gamma radiation, P:DNA damage checkpoint, P:DNA damage induced protein phosphorylation, P:DNA repair, P:female gamete generation, P:heart development, P:histone mRNA catabolic process, P:intrinsic apoptotic signaling pathway in response to DNA damage, P:lipoprotein catabolic process, P:mitotic spindle assembly checkpoint, P:negative regulation of B cell proliferation, P:neuron apoptotic process, P:oocyte development, P:positive regulation of DNA damage response, signal transduction by p53 class mediator, P:positive regulation of neuron apoptotic process, P:protein autophosphorylation, P:protein phosphorylation, P:response to hypoxia, P:response to ionizing radiation, P:signal transduction involved in mitotic G2 DNA damage checkpoint, P:somitogenesis, C:chromosome, telomeric region, C:cytoplasm, C:nucleus, C:spindle, F:1-phosphatidylinositol-3-kinase activity, F:ATP binding, F:DNA-dependent protein kinase activity, F:histone serine kinase activity, F:protein kinase activity, P:brain development, P:cell cycle arrest, P:cellular response to DNA damage stimulus, P:cellular response to gamma radiation, P:DNA damage checkpoint, P:DNA damage induced protein phosphorylation, P:DNA repair, P:female gamete generation, P:heart development, P:histone mRNA catabolic process, P:intrinsic apoptotic signaling pathway in response to DNA damage, P:lipoprotein catabolic process, P:mitotic spindle assembly checkpoint, P:negative regulation of B cell proliferation, P:neuron apoptotic process, P:oocyte development, P:positive regulation of DNA damage response, signal transduction by p53 class mediator, P:positive regulation of neuron apoptotic process, P:protein autophosphorylation, P:protein phosphorylation, P:response to hypoxia, P:response to ionizing radiation, P:signal transduction involved in mitotic G2 DNA damage checkpoint, P:somitogenesis
UniProtAcetylation, ATP-binding, Cell cycle, Complete proteome, Cytoplasmic vesicle, DNA damage, DNA-binding, Kinase, Nucleotide-binding, Nucleus, Phosphoprotein, Reference proteome, Serine/threonine-protein kinase, Transferase, Tumor suppressor
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.14< 0.05RNA microarray21752957
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.59< 0.05RNA microarray21752957
Exp24172336Mus musculus6kidneycortexAKI (AKI)1.550.00236776LC-MS/MS24172336
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)0.270.0000104RNA microarray24569379
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.290.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium