CKDdb-logoCKDdb - Molecule ID A1315

geneBHLHB2, BHLHE40, 37226
nameClass E basic helix-loop-helix protein 40
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
BHE40_HUMANO14503ENSG000001341078553Hs.744856604256

Functions and classifications

GOC:Golgi apparatus, C:nucleolus, F:E-box binding, F:MRF binding, F:protein homodimerization activity, F:RNA polymerase II activating transcription factor binding, F:RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in negative regulation of transcription, F:RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity, F:RNA polymerase II transcription factor binding transcription factor activity involved in negative regulation of transcription, P:circadian regulation of gene expression, P:entrainment of circadian clock by photoperiod, P:negative regulation of sequence-specific DNA binding transcription factor activity, P:negative regulation of transcription from RNA polymerase II promoter, P:transcription from RNA polymerase II promoter, P:regulation of neuronal synaptic plasticity, C:Golgi apparatus, F:DNA binding, P:circadian rhythm, P:negative regulation of transcription, DNA-dependent, P:regulation of neuronal synaptic plasticity
UniProtComplete proteome, DNA-binding, Nucleus, Reference proteome, Transcription, Transcription regulation, Ubl conjugation, Phosphoprotein
PADBtranscription and translation, gene regulation

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)2.840.000314RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)3.130.00277RNA microarray19698090
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.356.38E-06RNA microarray20019191
Exp20847290Homo sapiens30kidneyglomeruliGlomerulonephritis (FSGS + COLL)4.010.0467RNA microarray20847290
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.33< 0.05RNA microarray21752957
Exp23809614aHomo sapiens83bloodwholeChronic_Renal_Insufficiency (End-stage renal failure)0.181.64E-13RNA microarray23809614
Exp23809614bHomo sapiens32bloodwholeChronic_Renal_Insufficiency (End-stage renal failure)0.115.93E-09RNA microarray23809614
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)2.490.00000373RNA microarray24569379

Compile date 08-10-2018© iMODE-CKD consortium