CKDdb-logoCKDdb - Molecule ID A1276

geneCLU, APOJ, CLI
nameClusterin precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
CLUS_HUMANP10909ENSG000001208851191Hs.436657185430

Functions and classifications

GOC:chromaffin granule, C:cytosol, C:endoplasmic reticulum, C:mitochondrial membrane, C:mitochondrion, C:nucleus, C:perinuclear region of cytoplasm, C:platelet alpha granule lumen, C:spherical high-density lipoprotein particle, F:misfolded protein binding, F:ubiquitin protein ligase binding, P:chaperone-mediated protein folding, P:complement activation, P:complement activation, classical pathway, P:innate immune response, P:intrinsic apoptotic signaling pathway, P:lipid metabolic process, P:negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage, P:negative regulation of protein homooligomerization, P:platelet activation, P:platelet degranulation, P:positive regulation of apoptotic process, P:positive regulation of intrinsic apoptotic signaling pathway, P:positive regulation of NF-kappaB transcription factor activity, P:positive regulation of proteasomal ubiquitin-dependent protein catabolic process, P:positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process, P:protein stabilization, P:release of cytochrome c from mitochondria, P:response to misfolded protein, P:response to virus, P:reverse cholesterol transport, P:cell death, C:aggresome, C:chromaffin granule, C:growth cone, P:cellular response to growth factor stimulus, P:endocrine pancreas development, P:negative regulation of apoptotic process, P:neuron projection morphogenesis, P:positive regulation of cell differentiation, P:positive regulation of cell proliferation, P:response to oxidative stress, C:aggresome, P:response to wounding
UniProtAlternative splicing, Apoptosis, Chaperone, Complement pathway, Complete proteome, Cytoplasm, Cytoplasmic vesicle, Direct protein sequencing, Disulfide bond, Endoplasmic reticulum, Glycoprotein, Immunity, Innate immunity, Membrane, Microsome, Mitochondrion, Nucleus, Polymorphism, Reference proteome, Secreted, Signal, Ubl conjugation, Lipoprotein
PADBchaperone, chaperonin

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp15042541Homo sapiens4kidneyglomeruliDiabetes (diabetic nephropathy)3< 0.01RNA microarray15042541
Exp17003339aMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)3.69< 0.05cDNA microarray17003339
Exp17003339bMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)4.37< 0.05cDNA microarray17003339
Exp17301227Homo sapiens13bloodserumFabry (6 months of ERT) 0.1602nanoLC-ESI-MS/MS17301227
Exp17579666cMus musculus6 to 12kidneywholeremnant_kidney_model (remnant kidney model)3.40.05RNA microarray17579666
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)4.590.02cDNA microarray19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)3.010.01cDNA microarray19099603
Exp19698090aHomo sapiens17bloodmononuclear cellsChronic_Renal_Insufficiency (Chronic kidney disease)0.460.0102496RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.470.0171RNA microarray19698090
Exp20181666aMus musculus6kidney IRI (ischemic injury model)7.6< 0.05RNA microarray20181666
Exp20181666bMus musculus6kidney IRI (ischemic injury model)7.4< 0.05RNA microarray20181666
Exp20181666cMus musculus6kidney IRI (ischemic injury model)4< 0.05RNA microarray20181666
Exp20411046Homo sapiens5kidneycyst fluidPolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease) < 0.001LC-MS/MS20411046
Exp20411046Homo sapiens5kidneycyst fluidPolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease) < 0.001LC-MS/MS20411046
Exp20411046Homo sapiens5kidneycyst fluidPolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease) < 0.001LC-MS/MS20411046
Exp20813037cRattus norvegicus6kidneywholePolycystic_Kidney_Disease (polycystic kidney disease)8.221.03E-11RNA microarray20813037
Exp21411733aMus musculus13macrophageF4/80hi cellsGlomerulonephritis (lupus nephritis)2.440.005cDNA microarray21411733
Exp21544065aRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D)2.83< 0.001MALDI-TOF/TOF21544065
Exp21544065bRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D)1.730.002MALDI-TOF/TOF21544065
Exp21544065cRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D)1.120.014MALDI-TOF/TOF21544065
Exp21698285Homo sapiens124urine Fabry (naive female Fabry)0.625.58E-03CE-MS21698285
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.78< 0.05RNA microarray21752957
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)46.43< 0.05RNA microarray21752957
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)47.32< 0.05RNA microarray21752957
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)6.84< 0.05RNA microarray21752957
Exp22172726Homo sapiens20kidneyglomeruliDiabetes (type 2 diabetic nephropathy)2.420.0001QSTAR Elite LC-MS/MS22172726
Exp22536212Homo sapiens86urinewholeDiabetes (type 2 diabetic nephropathy)0.630hybrid quadrupole-TOF, LC-MS/MS22536212
Exp23326503Rattus norvegicus kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease)7.684.44E-08mRNA microarray23326503
Exp23344851Rattus norvegicus14urineexosomeDiabetes (diabetic nephropathy)1.72 nLC-ESI-UHR-QToF-MS/MS23344851
Exp23506792aMus musculus10urinewholeDiclofenac_induced (diclofenac-induced renal injury) < 0.05MALDI-TOF MS23506792
Exp24096133dHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy vs type 1 diabetes without retinopathy or nephropathy)2.25 1DE, MALDI24096133
Exp24096133fHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy and nephropathy vs type 1 diabetes with retinopathy)0.44 1DE, MALDI24096133
Exp24172336Mus musculus6kidneycortexAKI (AKI)11.150.017620295LC-MS/MS24172336
Exp24434790Homo sapiens10kidneyglomeruliGlomerulonephritis (IgA nephropathy)1.51< 0.05MALDI-TOF/TOF24434790
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)3.170.00000169RNA microarray24569379
Exp24726496Rattus norvegicus kidneyglomeruliDiabetes (diabetic nephropathy)  LC-MS/MS24726496
Exp25150443aHomo sapiens24urinesupernatantNephrotic_Syndrome (paediatric idiopathic nephrotic syndrome)2.68.90E-08LC-MS25150443

Compile date 08-10-2018© iMODE-CKD consortium