CKDdb-logoCKDdb - Molecule ID A126A

nameSecreted frizzled-related protein 2
speciesMus musculus

Molecule reference


Functions and classifications

GOC:cytoplasm, C:extracellular space, C:plasma membrane, F:endopeptidase activator activity, F:metalloenzyme activator activity, F:PDZ domain binding, F:protein binding, F:receptor agonist activity, F:Wnt-activated receptor activity, F:Wnt-protein binding, P:anterior/posterior pattern specification, P:apoptotic process, P:bone morphogenesis, P:brain development, P:cardiac left ventricle morphogenesis, P:cartilage development, P:cell death, P:cellular response to extracellular stimulus, P:cellular response to X-ray, P:chondrocyte development, P:collagen fibril organization, P:convergent extension involved in axis elongation, P:development of primary male sexual characteristics, P:digestive tract morphogenesis, P:embryonic digit morphogenesis, P:hematopoietic stem cell proliferation, P:male gonad development, P:negative regulation of BMP signaling pathway, P:negative regulation of canonical Wnt signaling pathway, P:negative regulation of cardiac muscle cell apoptotic process, P:negative regulation of cell growth, P:negative regulation of cell migration, P:negative regulation of cysteine-type endopeptidase activity involved in apoptotic process, P:negative regulation of dermatome development, P:negative regulation of epithelial cell proliferation, P:negative regulation of epithelial to mesenchymal transition, P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, P:negative regulation of gene expression, P:negative regulation of JUN kinase activity, P:negative regulation of mesodermal cell fate specification, P:negative regulation of peptidyl-tyrosine phosphorylation, P:negative regulation of planar cell polarity pathway involved in axis elongation, P:negative regulation of transcription, DNA-templated, P:negative regulation of Wnt signaling pathway, P:neural tube closure, P:neural tube development, P:outflow tract morphogenesis, P:patterning of blood vessels, P:planar cell polarity pathway involved in neural tube closure, P:positive regulation of angiogenesis, P:positive regulation of apoptotic process, P:positive regulation of canonical Wnt signaling pathway, P:positive regulation of catenin import into nucleus, P:positive regulation of cell growth, P:positive regulation of cell proliferation, P:positive regulation of endopeptidase activity, P:positive regulation of fat cell differentiation, P:positive regulation of osteoblast differentiation, P:positive regulation of peptidyl-serine phosphorylation, P:positive regulation of transcription from RNA polymerase II promoter, P:post-anal tail morphogenesis, P:regulation of apoptotic process, P:regulation of cell proliferation, P:regulation of establishment of planar polarity, P:regulation of stem cell division, P:regulation of Wnt signaling pathway, P:response to drug, P:response to nutrient, P:sclerotome development, P:somitogenesis, P:Wnt signaling pathway involved in somitogenesis, C:extracellular region, P:negative regulation of canonical Wnt receptor signaling pathway, P:negative regulation of transcription, DNA-dependent, P:positive regulation of canonical Wnt receptor signaling pathway, P:Wnt receptor signaling pathway involved in somitogenesis
UniProtComplete proteome, Developmental protein, Differentiation, Disulfide bond, Reference proteome, Secreted, Signal, Wnt signaling pathway

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp16316330bRattus norvegicus10kidneycortexGlomerulonephritis (Thy_1_nephritis)0.31< 0.01cDNA microarray16316330
Exp17003339aMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)1.69< 0.05cDNA microarray17003339
Exp17003339bMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)0.9< 0.05cDNA microarray17003339
Exp17579666aMus musculus6 to 12kidneywholeremnant_kidney_model (remnant kidney model)2.260.05RNA microarray17579666
Exp23760282aMus musculus kidneywholeureteral_obstruction (renal tubulointerstitial injury)0.30.022RNA microarray23760282

Compile date 08-10-2018© iMODE-CKD consortium