CKDdb-logoCKDdb - Molecule ID A125J

geneAVPR2, ADHR, DIR
nameVasopressin V2 receptor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
V2R_HUMANP30518ENSG00000126895554Hs.567240300538, 300539, 304800

Functions and classifications

GOC:endoplasmic reticulum, C:endosome, C:Golgi apparatus, C:integral component of plasma membrane, F:vasopressin receptor activity, P:activation of adenylate cyclase activity, P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway, P:excretion, P:hemostasis, P:I-kappaB kinase/NF-kappaB signaling, P:interferon-gamma production, P:negative regulation of renal sodium excretion, P:negative regulation of urine volume, P:positive regulation of cell proliferation, P:positive regulation of gene expression, P:positive regulation of protein ubiquitination, P:positive regulation of systemic arterial blood pressure, P:response to cytokine, P:telencephalon development, P:transmembrane transport, P:water transport, C:integral component of membrane, C:integral to plasma membrane, P:I-kappaB kinase/NF-kappaB cascade, P:response to cytokine stimulus, C:integral to membrane
UniProt3D-structure, Alternative splicing, Cell membrane, Complete proteome, Diabetes insipidus, Disease mutation, G-protein coupled receptor, Glycoprotein, Lipoprotein, Membrane, Palmitate, Polymorphism, Receptor, Reference proteome, Transducer, Transmembrane, Transmembrane helix
PADBreceptor

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19099603bMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)2.470.01cDNA microarray19099603
Exp19698090aHomo sapiens17bloodmononuclear cellsChronic_Renal_Insufficiency (Chronic kidney disease)0.390.0250605RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.090.000000286RNA microarray19698090
Exp23192593Rattus norvegicus32kidneycortexGlomerulonephritis (mesangioproliferative glomerulonephritis)6.020.0063RNA microarray23192593

Compile date 08-10-2018© iMODE-CKD consortium