CKDdb-logoCKDdb - Molecule ID A1193

geneBACE, BACE1, HSPC104
nameBeta-secretase 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
BACE1_HUMANP56817ENSP0000031858523621Hs.504003604252

Functions and classifications

GOC:axon, C:cell surface, C:cytoplasmic vesicle membrane, C:endoplasmic reticulum, C:endosome, C:Golgi apparatus, C:integral component of plasma membrane, C:trans-Golgi network, F:aspartic-type endopeptidase activity, F:beta-aspartyl-peptidase activity, P:beta-amyloid metabolic process, P:membrane protein ectodomain proteolysis, P:proteolysis, C:integral to plasma membrane
UniProt3D-structure, Alternative splicing, Aspartyl protease, Complete proteome, Cytoplasmic vesicle, Direct protein sequencing, Disulfide bond, Endoplasmic reticulum, Endosome, Glycoprotein, Golgi apparatus, Hydrolase, Membrane, Polymorphism, Protease, Reference proteome, Signal, Transmembrane, Transmembrane helix, Zymogen
PADBENZ: enzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.26< 0.05RNA microarray21752957

Compile date 08-10-2018© iMODE-CKD consortium