CKDdb-logoCKDdb - Molecule ID A1180

geneBcl3
nameB-cell lymphoma 3 protein homolog
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
BCL3_MOUSEQ9Z2F6ENSMUSG0000005317512051Mm.439658109560

Functions and classifications

GOC:Bcl3-Bcl10 complex, C:Bcl3/NF-kappaB2 complex, C:nucleus, C:perinuclear region of cytoplasm, F:DNA binding, F:protein binding, F:sequence-specific DNA binding transcription factor activity, P:antimicrobial humoral response, P:defense response to bacterium, P:defense response to protozoan, P:DNA damage response, signal transduction by p53 class mediator, P:extracellular matrix organization, P:follicular dendritic cell differentiation, P:germinal center formation, P:humoral immune response mediated by circulating immunoglobulin, P:I-kappaB kinase/NF-kappaB signaling, P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, P:marginal zone B cell differentiation, P:negative regulation of apoptotic process, P:negative regulation of interleukin-8 biosynthetic process, P:negative regulation of transcription, DNA-templated, P:negative regulation of tumor necrosis factor biosynthetic process, P:positive regulation of interferon-gamma production, P:positive regulation of interleukin-10 biosynthetic process, P:positive regulation of transcription from RNA polymerase II promoter, P:positive regulation of translation, P:protein import into nucleus, translocation, P:regulation of DNA binding, P:regulation of NF-kappaB import into nucleus, P:response to UV-C, P:response to virus, P:spleen development, P:T-helper 1 type immune response, P:T-helper 2 cell differentiation, P:transcription, DNA-templated, F:DNA binding, F:sequence-specific DNA binding transcription factor activity, P:antimicrobial humoral response, P:defense response to bacterium, P:defense response to protozoan, P:extracellular matrix organization, P:follicular dendritic cell differentiation, P:germinal center formation, P:humoral immune response mediated by circulating immunoglobulin, P:marginal zone B cell differentiation, P:negative regulation of apoptotic process, P:negative regulation of tumor necrosis factor biosynthetic process, P:positive regulation of interferon-gamma production, P:positive regulation of interleukin-10 biosynthetic process, P:positive regulation of transcription from RNA polymerase II promoter, P:spleen development, P:T-helper 1 type immune response, P:T-helper 2 cell differentiation, F:DNA binding, F:sequence-specific DNA binding transcription factor activity, P:antimicrobial humoral response, P:defense response to bacterium, P:defense response to protozoan, P:extracellular matrix organization, P:follicular dendritic cell differentiation, P:germinal center formation, P:humoral immune response mediated by circulating immunoglobulin, P:marginal zone B cell differentiation, P:negative regulation of apoptotic process, P:negative regulation of tumor necrosis factor biosynthetic process, P:positive regulation of interferon-gamma production, P:positive regulation of interleukin-10 biosynthetic process, P:positive regulation of transcription from RNA polymerase II promoter, P:spleen development, P:T-helper 1 type immune response, P:T-helper 2 cell differentiation, C:Bcl3-Bcl10 complex, C:Bcl3/NF-kappaB2 complex, C:cytoplasm, C:nucleus, F:DNA binding, F:sequence-specific DNA binding transcription factor activity, P:antimicrobial humoral response, P:defense response to bacterium, P:defense response to protozoan, P:DNA damage response, signal transduction by p53 class mediator, P:extracellular matrix organization, P:follicular dendritic cell differentiation, P:germinal center formation, P:humoral immune response mediated by circulating immunoglobulin, P:I-kappaB kinase/NF-kappaB signaling, P:intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, P:marginal zone B cell differentiation, P:negative regulation of apoptotic process, P:negative regulation of interleukin-8 biosynthetic process, P:negative regulation of transcription, DNA-templated, P:negative regulation of tumor necrosis factor biosynthetic process, P:positive regulation of interferon-gamma production, P:positive regulation of interleukin-10 biosynthetic process, P:positive regulation of transcription from RNA polymerase II promoter, P:positive regulation of translation, P:protein import into nucleus, translocation, P:regulation of DNA binding, P:regulation of NF-kappaB import into nucleus, P:response to UV-C, P:response to virus, P:spleen development, P:T-helper 1 type immune response, P:T-helper 2 cell differentiation, P:transcription, DNA-templated
UniProtActivator, ANK repeat, Complete proteome, Cytoplasm, Nucleus, Phosphoprotein, Reference proteome, Repeat, Transcription, Transcription regulation, Ubl conjugation
PADBtranscription and translation, gene regulation

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17327501aMus musculus6kidneywholeIAKI (Ischemic acute kidney injury)643.59< 0.05RNA microarray17327501
Exp17327501bMus musculus6kidneywholeIAKI (Ischemic acute kidney injury)8.63< 0.05RNA microarray17327501
Exp18187931aMus musculus20kidneyglomeruliGlomerulonephritis (lupus nephritis)12.1< 0.05RNA microarray18187931
Exp21411733aMus musculus13macrophageF4/80hi cellsGlomerulonephritis (lupus nephritis)2.530cDNA microarray21411733
Exp21411733bMus musculus11macrophageF4/80hi cellsGlomerulonephritis (lupus nephritis)0.370cDNA microarray21411733
Exp21659735Homo sapiens kidneymesangial cellsDiabetes (diabetic nephropathy)2.7 MALDI-TOF-MS21659735
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)2.650.00000875RNA microarray24569379
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.344.42E-05RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium