CKDdb-logoCKDdb - Molecule ID A1177

geneA2m, Pzp
nameAlpha-2-macroglobulin
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
A2M_MOUSEQ61838ENSMUSG00000073491100911545Rn.225884103950

Functions and classifications

GOC:extracellular space, F:endopeptidase inhibitor activity, F:peptidase inhibitor activity, F:serine-type endopeptidase inhibitor activity, P:acute-phase response, P:inflammatory response, P:negative regulation of endopeptidase activity, P:response to carbon dioxide, P:response to glucocorticoid, P:response to nutrient, P:response to wounding, F:receptor binding, P:negative regulation of complement activation, lectin pathway, P:response to glucocorticoid stimulus, P:stem cell differentiation
UniProtAcute phase, Bait region, Complete proteome, Disulfide bond, Glycoprotein, Protease inhibitor, Reference proteome, Secreted, Serine protease inhibitor, Signal, Thioester bond
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseBiomarkerFold change in diseaseP-valueDetectionMol. modificationValidationPubMed/DOI
Exp17579666cMus musculus6 to 12kidneywholeremnant_kidney_model (remnant kidney model) 4.910.05RNA microarray  17579666
Exp19845401Mus musculus32eyesretinaDiabetes (diabetic retinopathy) 0.3< 0.05LC-MS/MS  19845401
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis) 3.513.23E-06RNA microarray  20019191
Exp20093355Homo sapiens33kidney Fibrosis (Interstitial fibrosis and tubular atrophy) up MS/MS, LTQ LX linear ion trap  20093355
Exp20812764Homo sapiens13bloodplasmaTransplantation (Acute Renal Allograft Rejection) 0.190LC-MS/MS  20812764
Exp20813037cRattus norvegicus6kidneywholePolycystic_Kidney_Disease (polycystic kidney disease) 8.464.48E-10RNA microarray  20813037
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease) 6.33< 0.05RNA microarray  21752957
Exp22172726Homo sapiens20kidneyglomeruliDiabetes (type 2 diabetic nephropathy) 0.780.0247QSTAR Elite LC-MS/MS  22172726
Exp22536212Homo sapiens86urinewholeDiabetes (type 2 diabetic nephropathy) 3.040hybrid quadrupole-TOF, LC-MS/MS  22536212
Exp23228063Homo sapiens30urinewholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease) 3.160.00003LC-MS/MS  23228063
Exp23326503Rattus norvegicus kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease) 2.980.0000086mRNA microarray  23326503
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy) 27.15< 0.05RNA-seq  23757392
Exp23757392bRattus norvegicus13kidneywholeDiabetes (diabetic nephropathy) 16.11< 0.05RNA-seq  23757392
Exp24096133cHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy and nephropathy) 1000 1DE, MALDI  24096133
Exp24096133eHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy and nephropathy vs type 1 diabetes without retinopathy or nephropathy) 1000 1DE, MALDI  24096133
Exp24096133fHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy and nephropathy vs type 1 diabetes with retinopathy) 1000 1DE, MALDI  24096133
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI) 0.470.00517RNA microarray  24569379
Exp25150443aHomo sapiens24urinesupernatantNephrotic_Syndrome (paediatric idiopathic nephrotic syndrome) 3.75.20E-05LC-MS  25150443

Compile date 08-30-2016© iMODE-CKD consortium