CKDdb-logoCKDdb - Molecule ID A1176

geneAPOE
nameApolipoprotein E precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
APOE_HUMANP02649ENSG00000130203348Hs.654439104310, 107741, 143890, 269600, 611771

Functions and classifications

GOC:chylomicron, C:dendrite, C:early endosome, C:endocytic vesicle lumen, C:extrinsic component of external side of plasma membrane, C:Golgi apparatus, C:high-density lipoprotein particle, C:intermediate-density lipoprotein particle, C:late endosome, C:low-density lipoprotein particle, C:neuronal cell body, C:plasma membrane, C:very-low-density lipoprotein particle, F:antioxidant activity, F:beta-amyloid binding, F:cholesterol transporter activity, F:heparin binding, F:hydroxyapatite binding, F:lipid transporter activity, F:lipoprotein particle binding, F:low-density lipoprotein particle receptor binding, F:metal chelating activity, F:phosphatidylcholine-sterol O-acyltransferase activator activity, F:phospholipid binding, F:protein homodimerization activity, F:very-low-density lipoprotein particle receptor binding, P:aging, P:artery morphogenesis, P:cell death, P:cellular calcium ion homeostasis, P:cellular response to cholesterol, P:cellular response to growth factor stimulus, P:cellular response to interleukin-1, P:cGMP-mediated signaling, P:cholesterol catabolic process, P:cholesterol efflux, P:cholesterol homeostasis, P:cholesterol metabolic process, P:chylomicron remnant clearance, P:cytoskeleton organization, P:G-protein coupled receptor signaling pathway, P:high-density lipoprotein particle assembly, P:high-density lipoprotein particle clearance, P:high-density lipoprotein particle remodeling, P:intracellular transport, P:lipoprotein biosynthetic process, P:lipoprotein catabolic process, P:lipoprotein metabolic process, P:low-density lipoprotein particle remodeling, P:maintenance of location in cell, P:negative regulation of blood vessel endothelial cell migration, P:negative regulation of cholesterol biosynthetic process, P:negative regulation of endothelial cell proliferation, P:negative regulation of inflammatory response, P:negative regulation of MAP kinase activity, P:negative regulation of neuron apoptotic process, P:negative regulation of platelet activation, P:nitric oxide mediated signal transduction, P:oligodendrocyte differentiation, P:peripheral nervous system axon regeneration, P:phospholipid efflux, P:phototransduction, visible light, P:positive regulation of axon extension, P:positive regulation of cGMP biosynthetic process, P:positive regulation of cholesterol efflux, P:positive regulation of cholesterol esterification, P:positive regulation of low-density lipoprotein particle receptor catabolic process, P:positive regulation of membrane protein ectodomain proteolysis, P:positive regulation of nitric-oxide synthase activity, P:receptor-mediated endocytosis, P:regulation of axon extension, P:regulation of Cdc42 protein signal transduction, P:regulation of gene expression, P:regulation of neuronal synaptic plasticity, P:response to dietary excess, P:response to ethanol, P:response to insulin, P:response to reactive oxygen species, P:response to retinoic acid, P:retinoid metabolic process, P:reverse cholesterol transport, P:synaptic transmission, cholinergic, P:triglyceride metabolic process, P:vasodilation, P:very-low-density lipoprotein particle clearance, P:very-low-density lipoprotein particle remodeling, P:positive regulation of catalytic activity, P:response to oxidative stress, C:extracellular region, F:lipid binding, P:lipid transport, C:cytoplasm, C:extrinsic to external side of plasma membrane, C:microtubule, P:induction of apoptosis, P:negative regulation of apoptotic process, C:extracellular space
UniProt3D-structure, Alzheimer disease, Amyloidosis, Cholesterol metabolism, Chylomicron, Complete proteome, Direct protein sequencing, Disease mutation, Glycation, Glycoprotein, HDL, Heparin-binding, Hyperlipidemia, Lipid metabolism, Lipid transport, Neurodegeneration, Oxidation, Phosphoprotein, Polymorphism, Reference proteome, Repeat, Secreted, Signal, Steroid metabolism, Sterol metabolism, Transport, VLDL, Lipoprotein
PADBtransport, storage, endocytosis, exocytosis, vesicles

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionValidationPubMed/DOI
Exp17003339aMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)3< 0.05cDNA microarray 17003339
Exp17003339bMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)3.32< 0.05cDNA microarray 17003339
Exp17579666cMus musculus6 to 12kidneywholeremnant_kidney_model (remnant kidney model)4.620.05RNA microarray 17579666
Exp18187931aMus musculus20kidneyglomeruliGlomerulonephritis (lupus nephritis)5< 0.05RNA microarray 18187931
Exp18187931bMus musculus18kidneyglomeruliGlomerulonephritis (lupus nephritis)3.1< 0.05RNA microarray 18187931
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.290.00000461RNA microarray 19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.310.00000472RNA microarray 19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.320.0188RNA microarray 19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.450.0223RNA microarray 19698090
Exp20007950aRattus norvegicus8corporawholeDiabetes (Diabetes Mellitus-associated Erectile Dysfunction)0.510.011MALDI-TOF, LC-MS/MS 20007950
Exp20007950bRattus norvegicus8corporawholeDiabetes (Diabetes Mellitus-associated Erectile Dysfunction)0.890.011MALDI-TOF, LC-MS/MS 20007950
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.397.27E-05RNA microarray 20019191
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.418.81E-05RNA microarray 20019191
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.454.60E-05RNA microarray 20019191
Exp20543976Homo sapiens40urinewholeTransplantation (acute renal allograft rejection)0.1 LC-MS/MS 20543976
Exp21544065aRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D)0.95< 0.001MALDI-TOF/TOF 21544065
Exp21544065bRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D)0.410.01MALDI-TOF/TOF 21544065
Exp21544065cRattus norvegicus17kidney Diabetes (diabetic nephropathy in T1D)0.850.004MALDI-TOF/TOF 21544065
Exp22172726Homo sapiens20kidneyglomeruliDiabetes (type 2 diabetic nephropathy)1.680.01QSTAR Elite LC-MS/MS 22172726
Exp23228063Homo sapiens30urinewholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic Kidney disease)0.690.04059LC-MS/MS 23228063
Exp23344851Rattus norvegicus14urineexosomeDiabetes (diabetic nephropathy)1.51 nLC-ESI-UHR-QToF-MS/MS 23344851
Exp23935909Homo sapiens24bloodmonocytesChronic_Renal_Insufficiency (Chronic kidney disease)0.20.0040619RNA microarray 23935909
Exp24726496Rattus norvegicus kidneyglomeruliDiabetes (diabetic nephropathy)0.150.001LC-MS/MS 24726496
Exp25619383Homo sapiens46bloodplasmaFabry (Fabry) 0LC-MS/MSMRM25619383

Compile date 08-10-2018© iMODE-CKD consortium