CKDdb-logoCKDdb - Molecule ID A1169

geneAPP, A4, AD1
nameAmyloid beta A4 protein
speciesHomo sapiens

Molecule reference

A4_HUMANP05067ENSG00000142192351Hs.434980104300, 104760, 605714

Functions and classifications

GOC:apical part of cell, C:axon, C:cell surface, C:ciliary rootlet, C:coated pit, C:cytosol, C:dendritic shaft, C:dendritic spine, C:extracellular region, C:Golgi apparatus, C:integral component of plasma membrane, C:neuromuscular junction, C:perinuclear region of cytoplasm, C:platelet alpha granule lumen, C:spindle midzone, C:synapse, F:DNA binding, F:heparin binding, F:peptidase activator activity, F:serine-type endopeptidase inhibitor activity, F:transition metal ion binding, P:adult locomotory behavior, P:axon cargo transport, P:axon midline choice point recognition, P:cell adhesion, P:cellular copper ion homeostasis, P:cholesterol metabolic process, P:collateral sprouting in absence of injury, P:dendrite development, P:endocytosis, P:extracellular matrix organization, P:forebrain development, P:innate immune response, P:ionotropic glutamate receptor signaling pathway, P:mating behavior, P:mitotic G2 phase, P:mRNA polyadenylation, P:negative regulation of neuron differentiation, P:neuromuscular process controlling balance, P:neuron apoptotic process, P:neuron remodeling, P:Notch signaling pathway, P:nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway, P:platelet activation, P:platelet degranulation, P:positive regulation of G2/M transition of mitotic cell cycle, P:positive regulation of mitotic cell cycle, P:positive regulation of transcription from RNA polymerase II promoter, P:protein phosphorylation, P:regulation of epidermal growth factor-activated receptor activity, P:regulation of multicellular organism growth, P:regulation of protein binding, P:regulation of synapse structure and activity, P:regulation of translation, P:response to oxidative stress, P:smooth endoplasmic reticulum calcium ion homeostasis, P:suckling behavior, P:synaptic growth at neuromuscular junction, P:visual learning, C:integral component of membrane, C:cytoplasmic vesicle, C:plasma membrane, F:peptidase activity, P:negative regulation of endopeptidase activity, P:proteolysis, C:integral to plasma membrane, P:G2 phase of mitotic cell cycle, P:induction of apoptosis, C:integral to membrane
UniProt3D-structure, Alternative splicing, Alzheimer disease, Amyloid, Amyloidosis, Apoptosis, Cell adhesion, Coated pit, Complete proteome, Copper, Direct protein sequencing, Disease mutation, Disulfide bond, Endocytosis, Glycoprotein, Heparin-binding, Iron, Membrane, Metal-binding, Neurodegeneration, Notch signaling pathway, Phosphoprotein, Polymorphism, Protease inhibitor, Proteoglycan, Reference proteome, Serine protease inhibitor, Signal, Transmembrane, Transmembrane helix, Zinc, Hydrolase, Protease
PADBCell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)2.020.000397RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)3.734.84E-08RNA microarray19698090
Exp20543976Homo sapiens40urinewholeTransplantation (acute renal allograft rejection)0.2 LC-MS/MS20543976
Exp20543976Homo sapiens40urinewholeTransplantation (acute renal allograft rejection)0.3 LC-MS/MS20543976
Exp25666440Homo sapiens23urinesupernatantFabry (naive Fabry patients)2.610.009813nanoLC-ESI-MS/MS25666440

Compile date 08-10-2018© iMODE-CKD consortium