CKDdb-logoCKDdb - Molecule ID A1115

geneCBLB, RNF56
nameSignal transduction protein CBL-B
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
CBLB_HUMANQ13191ENSG00000114423868Hs.430589604491

Functions and classifications

GOC:cytosol, C:nucleus, C:plasma membrane, F:calcium ion binding, F:signal transducer activity, F:ubiquitin-protein ligase activity, F:zinc ion binding, P:cell surface receptor signaling pathway, P:immune response, P:intracellular signal transduction, P:negative regulation of alpha-beta T cell proliferation, P:negative regulation of T cell receptor signaling pathway, P:NLS-bearing protein import into nucleus, P:positive regulation of protein catabolic process, P:positive regulation of T cell anergy, P:signal transduction, P:T cell activation, P:protein ubiquitination, P:regulation of signaling, C:cytoplasm, C:membrane raft, P:NLS-bearing substrate import into nucleus, P:response to gravity, P:response to hormone stimulus
UniProt3D-structure, Alternative splicing, Calcium, Complete proteome, Cytoplasm, Ligase, Metal-binding, Phosphoprotein, Polymorphism, Reference proteome, Repeat, Ubl conjugation, Ubl conjugation pathway, Zinc, Zinc-finger
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.330.0156RNA microarray19698090
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.14< 0.05RNA microarray21752957
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)2.73.35E-08RNA microarray24569379

Compile date 08-10-2018© iMODE-CKD consortium