CKDdb-logoCKDdb - Molecule ID A1105

geneBTRC, BTRCP, FBW1A
nameF-box/WD-repeat protein 1A
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
FBW1A_HUMANQ9Y297ENSG000001661678945Hs.643802603482

Functions and classifications

GOC:cytosol, C:nucleus, C:SCF ubiquitin ligase complex, F:ubiquitin-protein ligase activity, P:anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process, P:branching involved in mammary gland duct morphogenesis, P:cellular response to organic cyclic compound, P:mammary gland epithelial cell proliferation, P:negative regulation of sequence-specific DNA binding transcription factor activity, P:negative regulation of smoothened signaling pathway, P:negative regulation of transcription, DNA-templated, P:positive regulation of circadian rhythm, P:positive regulation of proteolysis, P:positive regulation of transcription, DNA-templated, P:positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle, P:protein dephosphorylation, P:protein destabilization, P:protein polyubiquitination, P:protein ubiquitination, P:regulation of cell cycle, P:regulation of I-kappaB kinase/NF-kappaB signaling, P:regulation of proteasomal protein catabolic process, P:signal transduction, P:viral process, P:Wnt signaling pathway, F:ubiquitin-protein ligase activity, P:protein catabolic process, P:regulation of proteasomal protein catabolic process, F:ligase activity, P:negative regulation of transcription, DNA-dependent, P:positive regulation of transcription, DNA-dependent, P:regulation of I-kappaB kinase/NF-kappaB cascade, P:viral reproduction, P:virus-host interaction, P:Wnt receptor signaling pathway, P:branching involved in mammary gland duct morphogenesis
UniProt3D-structure, Alternative splicing, Complete proteome, Cytoplasm, Host-virus interaction, Ligase, Nucleus, Polymorphism, Reference proteome, Repeat, Ubl conjugation pathway, WD repeat, Wnt signaling pathway
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17609286Mus musculus10kidneyglomeruliDiabetes (diabetic nephropathy in Type 1 diabetes) < 0.05MALDI-TOF-MS17609286
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.210.000833RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.450.0218RNA microarray19698090
Exp23935909Homo sapiens24bloodmonocytesChronic_Renal_Insufficiency (Chronic kidney disease)4.40.043229RNA microarray23935909
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)0.360.00000285RNA microarray24569379

Compile date 08-10-2018© iMODE-CKD consortium