CKDdb-logoCKDdb - Molecule ID A1094

geneAGER, RAGE
nameAdvanced glycosylation end product-specific receptor precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
RAGE_HUMANQ15109ENSG00000204305177Hs.534342600214

Functions and classifications

GOC:extracellular region, C:integral component of plasma membrane, F:transmembrane signaling receptor activity, P:cell surface receptor signaling pathway, P:induction of positive chemotaxis, P:inflammatory response, P:innate immune response, P:neuron projection development, P:positive regulation of NF-kappaB transcription factor activity, C:membrane, C:axon, C:basal plasma membrane, C:cytoplasm, C:extracellular space, C:integral to plasma membrane, C:neuronal cell body, F:advanced glycation end-product receptor activity, P:brain development, P:calcium ion homeostasis, P:JAK-STAT cascade, P:lung development, P:positive regulation of apoptotic process, P:positive regulation of fibroblast migration, P:positive regulation of inflammatory response, P:positive regulation of smooth muscle cell proliferation, P:response to hyperoxia
UniProt3D-structure, Alternative splicing, Cell membrane, Complete proteome, Disulfide bond, Glycoprotein, Immunoglobulin domain, Inflammatory response, Membrane, Polymorphism, Reference proteome, Repeat, Secreted, Signal, Transmembrane, Transmembrane helix, Receptor
PADBreceptor

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19136817Mus musculus10kidneyglomeruliUrination_Disorders (proteinuria)0.40.00437RNA microarray19136817
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.330.00356RNA microarray19698090
Exp25770168Homo sapiens17bloodmononuclear cellsGlomerulonephritis (IgA nephropathy)4.920.003RNA microarray25770168
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.36.74E-04RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium