CKDdb-logoCKDdb - Molecule ID A1080

geneCOL18A1, MFP
nameCollagen alpha 1(XVIII) chain precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
COIA1_HUMANP39060ENSG0000018287180781Hs.517356120328, 267750

Functions and classifications

GOC:basement membrane, C:collagen, C:endoplasmic reticulum lumen, C:extracellular space, F:metal ion binding, F:structural molecule activity, P:angiogenesis, P:cell adhesion, P:collagen catabolic process, P:endothelial cell morphogenesis, P:extracellular matrix disassembly, P:negative regulation of cell proliferation, P:organ morphogenesis, P:positive regulation of cell migration, P:positive regulation of cell proliferation, P:positive regulation of endothelial cell apoptotic process, P:response to drug, P:response to hydrostatic pressure, P:visual perception, P:extracellular matrix organization, C:extracellular matrix, P:positive regulation of apoptotic process
UniProt3D-structure, Alternative promoter usage, Alternative splicing, Cell adhesion, Collagen, Complete proteome, Disulfide bond, Extracellular matrix, Glycoprotein, Hydroxylation, Metal-binding, Polymorphism, Reference proteome, Repeat, Secreted, Signal, Zinc
PADBCell shape (cytoskeleton, cell adhesion, morphology, cell junction, cellular structures, extracellular matrix)

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17003339aMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)1.22< 0.05cDNA microarray17003339
Exp17003339bMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)1.91< 0.05cDNA microarray17003339
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.320.00000134RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.470.000819RNA microarray19698090
Exp21698285Homo sapiens124urine Fabry (naive female Fabry)0.512.47E-02CE-MS21698285
Exp21698285Homo sapiens124urine Fabry (naive female Fabry)1.113.39E-02CE-MS21698285
Exp21698285Homo sapiens124urine Fabry (naive female Fabry)2.671.61E-05CE-MS21698285
Exp22172726Homo sapiens20kidneyglomeruliDiabetes (type 2 diabetic nephropathy)1.230.0001QSTAR Elite LC-MS/MS22172726
Exp22536212Homo sapiens86urinewholeDiabetes (type 2 diabetic nephropathy)0.560.01hybrid quadrupole-TOF, LC-MS/MS22536212
Exp24096133aHomo sapiens10urine>10kDaDiabetes (type 1 diabetes without retinopathy or nephropathy)0 1DE, MALDI24096133
Exp24096133bHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy)0 1DE, MALDI24096133
Exp24096133eHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy and nephropathy vs type 1 diabetes without retinopathy or nephropathy)1000 1DE, MALDI24096133
Exp24096133fHomo sapiens10urine>10kDaDiabetes (type 1 diabetes with retinopathy and nephropathy vs type 1 diabetes with retinopathy)1000 1DE, MALDI24096133
Exp24172336Mus musculus6kidneycortexAKI (AKI)1.870.014321334LC-MS/MS24172336
Exp24189015aHomo sapiens5bloodmononuclear cellshealthy (healthy)3.72 +/- 0.32< 0.001RNA microarray24189015
Exp24189015aHomo sapiens5bloodmononuclear cellshealthy (healthy)3.95 +/- 0.41< 0.001RNA microarray24189015
Exp24189015bHomo sapiens9bloodmononuclear cellsChronic_Renal_Insufficiency (Chronic kidney disease)3.89 +/- 0.4< 0.001RNA microarray24189015
Exp24189015bHomo sapiens9bloodmononuclear cellsChronic_Renal_Insufficiency (Chronic kidney disease)4.29 +/- 0.5< 0.001RNA microarray24189015
Exp24189015cHomo sapiens10bloodmononuclear cellsDialysis (Peritoneal dialysis)2.69 +/- 0.57< 0.001RNA microarray24189015
Exp24189015cHomo sapiens10bloodmononuclear cellsDialysis (Peritoneal dialysis)2.76 +/- 0.84< 0.001RNA microarray24189015
Exp24189015dHomo sapiens17bloodmononuclear cellsDialysis (hemodialysis)2.84 +/- 0.39< 0.001RNA microarray24189015
Exp24189015dHomo sapiens17bloodmononuclear cellsDialysis (hemodialysis)3.00 +/- 0.56< 0.001RNA microarray24189015
Exp24904088Mus musculus24kidneyglomeruliGlomerulonephritis (FSGS)0.476.17E-10RNA microarray24904088
Exp24904088Mus musculus24kidneyglomeruliGlomerulonephritis (FSGS)0.476.17E-10RNA microarray24904088

Compile date 08-10-2018© iMODE-CKD consortium