CKDdb-logoCKDdb - Molecule ID A106F

geneARHGEF15
nameRho guanine nucleotide exchange factor 15
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ARHGF_HUMANO94989ENSG0000019884422899Hs.443109608504

Functions and classifications

GOC:cytoplasm, C:dendrite, F:GTPase activator activity, F:Rho guanyl-nucleotide exchange factor activity, P:negative regulation of synapse maturation, P:positive regulation of GTPase activity, P:positive regulation of stress fiber assembly, P:retina vasculature morphogenesis in camera-type eye, P:regulation of Rho GTPase activity, P:regulation of Rho protein signal transduction, C:intracellular
UniProtCell projection, Complete proteome, GTPase activation, Guanine-nucleotide releasing factor, Phosphoprotein, Polymorphism, Reference proteome, Ubl conjugation
PADBmodulator, regulator

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp15042541Homo sapiens4kidneyglomeruliDiabetes (diabetic nephropathy)3< 0.01RNA microarray15042541
Exp19698090aHomo sapiens17bloodmononuclear cellsChronic_Renal_Insufficiency (Chronic kidney disease)0.40.0183098RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.310.000217RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.360.000651RNA microarray19698090
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)0.210.00000193RNA microarray24569379
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)2.813.13E-03RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium