CKDdb-logoCKDdb - Molecule ID A1067

geneARHGEF12, LARG
nameRho guanine nucleotide exchange factor 12
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ARHGC_HUMANQ9NZN5ENSG0000019691423365Hs.24598604763

Functions and classifications

GOC:cytosol, C:membrane, F:G-protein coupled receptor binding, F:GTPase activator activity, F:Rho guanyl-nucleotide exchange factor activity, P:apoptotic signaling pathway, P:axon guidance, P:G-protein coupled receptor signaling pathway, P:neurotrophin TRK receptor signaling pathway, P:positive regulation of apoptotic process, P:positive regulation of GTPase activity, P:regulation of Rho GTPase activity, P:small GTPase mediated signal transduction, P:termination of G-protein coupled receptor signaling pathway, C:cytoplasm, P:intracellular signal transduction, F:phospholipid binding, P:apoptotic process, P:nerve growth factor receptor signaling pathway, P:regulation of Rho protein signal transduction, P:regulation of small GTPase mediated signal transduction
UniProt3D-structure, Acetylation, Alternative splicing, Chromosomal rearrangement, Coiled coil, Complete proteome, Cytoplasm, GTPase activation, Guanine-nucleotide releasing factor, Membrane, Phosphoprotein, Polymorphism, Proto-oncogene, Reference proteome
PADBtranscription and translation, gene regulation

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090aHomo sapiens17bloodmononuclear cellsChronic_Renal_Insufficiency (Chronic kidney disease)0.40.0370477RNA microarray19698090
Exp19698090aHomo sapiens17bloodmononuclear cellsChronic_Renal_Insufficiency (Chronic kidney disease)0.50.0225875RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.160.000837RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.330.0197RNA microarray19698090
Exp20485333Homo sapiens20bloodwholeGlomerulonephritis (IgA nephropathy)3.30.00109RNA microarray20485333
Exp20847290Homo sapiens30kidneyglomeruliGlomerulonephritis (FSGS + COLL)0.370.0735RNA microarray20847290
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.06< 0.05RNA microarray21752957
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.23< 0.05RNA microarray21752957
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.27< 0.05RNA microarray21752957
Exp24172336Mus musculus6kidneycortexAKI (AKI)10000.049762673LC-MS/MS24172336
Exp26317775aHomo sapiens53kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.491.45E-03RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium