CKDdb-logoCKDdb - Molecule ID A102G

geneDegs2
nameSphingolipid delta(4)-desaturase/C4-hydroxylase DES2
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGene
DEGS2_MOUSEQ8R2F2ENSMUSG0000002126370059Mm.207605

Functions and classifications

GOC:endoplasmic reticulum membrane, C:integral component of membrane, F:sphingolipid delta-4 desaturase activity, F:sphingosine hydroxylase activity, P:ceramide biosynthetic process, P:fatty acid biosynthetic process, P:sphinganine metabolic process, P:sphingolipid biosynthetic process, C:integral to membrane, F:oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
UniProtAlternative splicing, Complete proteome, Endoplasmic reticulum, Lipid biosynthesis, Lipid metabolism, Lipoprotein, Membrane, Myristate, Oxidoreductase, Reference proteome, Transmembrane, Transmembrane helix
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17003339aMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)0.27< 0.05cDNA microarray17003339
Exp17003339bMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)0.25< 0.05cDNA microarray17003339
Exp19099603bMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)2.020.03cDNA microarray19099603
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)4.650.02cDNA microarray19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)3.150cDNA microarray19099603

Compile date 08-10-2018© iMODE-CKD consortium