CKDdb-logoCKDdb - Molecule ID A0942

geneSocs2, Cis2, Cish2
nameSuppressor of cytokine signaling 2
speciesMus musculus

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
SOCS2_MOUSEO35717ENSMUSG00000020027216233Mm.474283605117

Functions and classifications

GOF:growth hormone receptor binding, F:insulin-like growth factor receptor binding, P:intracellular signal transduction, P:lactation, P:mammary gland alveolus development, P:negative regulation of JAK-STAT cascade, P:negative regulation of multicellular organism growth, P:positive regulation of neuron differentiation, P:protein ubiquitination, P:regulation of multicellular organism growth, F:growth hormone receptor binding, P:intracellular signal transduction, P:lactation, P:mammary gland alveolus development, P:negative regulation of JAK-STAT cascade, P:negative regulation of multicellular organism growth, P:positive regulation of neuron differentiation, P:regulation of multicellular organism growth, F:growth hormone receptor binding, P:intracellular signal transduction, P:lactation, P:mammary gland alveolus development, P:negative regulation of JAK-STAT cascade, P:negative regulation of multicellular organism growth, P:positive regulation of neuron differentiation, P:regulation of multicellular organism growth, F:growth hormone receptor binding, P:intracellular signal transduction, P:lactation, P:mammary gland alveolus development, P:negative regulation of JAK-STAT cascade, P:negative regulation of multicellular organism growth, P:positive regulation of neuron differentiation, P:protein ubiquitination, P:regulation of multicellular organism growth
UniProtComplete proteome, Growth regulation, Reference proteome, SH2 domain, Signal transduction inhibitor, Ubl conjugation pathway
PADBmodulator, regulator

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17003339aMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)0.46< 0.05cDNA microarray17003339
Exp17003339bMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)0.49< 0.05cDNA microarray17003339
Exp17579666cMus musculus6 to 12kidneywholeremnant_kidney_model (remnant kidney model)2.270.05RNA microarray17579666
Exp19099603cMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)2.140.01cDNA microarray19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)2.280.01cDNA microarray19099603
Exp19099603dMus musculus6kidneywholePolycystic_Kidney_Disease (Autosomal Dominant Polycystic kidney disease)2.380cDNA microarray19099603
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.27< 0.05RNA microarray21752957
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)2.140.00000376RNA microarray24569379
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)2.50.000000206RNA microarray24569379

Compile date 08-10-2018© iMODE-CKD consortium