CKDdb-logoCKDdb - Molecule ID A0902

geneBCR, BCR-ABL1, BCR1
nameBreakpoint cluster region protein
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
BCR_HUMANP11274ENSG00000186716613Hs.517461151410, 608232

Functions and classifications

GOC:cytosol, C:plasma membrane, F:ATP binding, F:GTPase activator activity, F:protein serine/threonine kinase activity, F:protein tyrosine kinase activity, F:Rac GTPase activator activity, F:Rho guanyl-nucleotide exchange factor activity, P:actin cytoskeleton organization, P:brain development, P:inner ear morphogenesis, P:negative regulation of cell migration, P:negative regulation of inflammatory response, P:negative regulation of neutrophil degranulation, P:neuromuscular process controlling balance, P:platelet-derived growth factor receptor signaling pathway, P:positive regulation of phagocytosis, P:protein autophosphorylation, P:regulation of cell cycle, P:regulation of small GTPase mediated signal transduction, P:response to lipopolysaccharide, P:small GTPase mediated signal transduction, C:intracellular, P:intracellular signal transduction, P:positive regulation of GTPase activity, P:regulation of Rho GTPase activity, P:signal transduction, F:phospholipid binding, P:regulation of Rho protein signal transduction
UniProt3D-structure, Alternative splicing, ATP-binding, Chromosomal rearrangement, Complete proteome, GTPase activation, Guanine-nucleotide releasing factor, Kinase, Nucleotide-binding, Phosphoprotein, Polymorphism, Proto-oncogene, Reference proteome, Serine/threonine-protein kinase, Transferase, SH3 domain
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090aHomo sapiens17bloodmononuclear cellsChronic_Renal_Insufficiency (Chronic kidney disease)0.40.0245788RNA microarray19698090
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)17.850.003182RNA microarray26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)4.850.008041RNA microarray26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)5.110.013999RNA microarray26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)6.210.014859RNA microarray26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)7.20.006791RNA microarray26317775
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)9.360.004547RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium