CKDdb-logoCKDdb - Molecule ID A0879

geneCASP1, IL1BC, IL1BCE
nameCaspase-1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
CASP1_HUMANP29466ENSG00000137752834Hs.2490147678

Functions and classifications

GOC:AIM2 inflammasome complex, C:cytosol, C:extracellular region, C:IPAF inflammasome complex, C:NLRP1 inflammasome complex, C:NLRP3 inflammasome complex, F:cysteine-type endopeptidase activator activity involved in apoptotic process, F:cysteine-type endopeptidase activity, P:cellular response to mechanical stimulus, P:cellular response to organic substance, P:innate immune response, P:interleukin-1 beta production, P:membrane hyperpolarization, P:mitochondrial depolarization, P:nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway, P:positive regulation of I-kappaB kinase/NF-kappaB signaling, P:positive regulation of interleukin-1 alpha secretion, P:positive regulation of interleukin-1 beta secretion, P:protein processing, P:proteolysis, P:pyroptosis, P:regulation of inflammatory response, P:response to ATP, P:response to hypoxia, P:response to lipopolysaccharide, C:intracellular, P:apoptotic process, P:regulation of apoptotic process, C:nucleus, P:induction of apoptosis, P:lung development, P:memory, P:microglial cell activation, P:midgut development, P:myoblast fusion, P:positive regulation of circadian sleep/wake cycle, non-REM sleep, P:positive regulation of I-kappaB kinase/NF-kappaB cascade, P:response to drug, P:response to lipopolysaccharide, P:response to toxin
UniProt3D-structure, Alternative splicing, Apoptosis, Complete proteome, Cytoplasm, Direct protein sequencing, Hydrolase, Polymorphism, Protease, Reference proteome, Thiol protease, Zymogen
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)3.131.15E-09RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)3.291.78E-09RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)4.52.07E-11RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)5.181.01E-09RNA microarray19698090
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)3.293.23E-06RNA microarray20019191
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)3.323.23E-06RNA microarray20019191
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)3.463.23E-06RNA microarray20019191
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)3.513.23E-06RNA microarray20019191
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)5.943.23E-06RNA microarray20019191
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)10.07< 0.05RNA microarray21752957
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)14.24< 0.05RNA microarray21752957
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)149.54< 0.05RNA microarray21752957
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)2.85< 0.05RNA microarray21752957
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)8.18< 0.05RNA microarray21752957
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.38< 0.05RNA microarray21752957
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)0.320.000843RNA microarray24569379

Compile date 08-10-2018© iMODE-CKD consortium