CKDdb-logoCKDdb - Molecule ID A0868

geneBIRC2, API1, IAP2
nameBaculoviral IAP repeat-containing protein 2
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
BIRC2_HUMANQ13490ENSG00000110330329Hs.696238601712

Functions and classifications

GOC:CD40 receptor complex, C:cytoplasmic side of plasma membrane, C:cytosol, C:membrane raft, C:nucleus, C:XY body, F:transcription coactivator activity, F:ubiquitin-protein ligase activity, F:zinc ion binding, P:cell surface receptor signaling pathway, P:cellular component disassembly involved in execution phase of apoptosis, P:innate immune response, P:necroptotic process, P:negative regulation of apoptotic process, P:NIK/NF-kappaB signaling, P:placenta development, P:positive regulation of I-kappaB kinase/NF-kappaB signaling, P:positive regulation of protein K48-linked ubiquitination, P:positive regulation of protein K63-linked ubiquitination, P:positive regulation of protein monoubiquitination, P:proteasome-mediated ubiquitin-dependent protein catabolic process, P:protein heterooligomerization, P:protein polyubiquitination, P:regulation of cell cycle, P:regulation of cell differentiation, P:regulation of cell proliferation, P:regulation of cysteine-type endopeptidase activity, P:regulation of inflammatory response, P:regulation of necroptotic process, P:regulation of nucleotide-binding oligomerization domain containing signaling pathway, P:regulation of RIG-I signaling pathway, P:regulation of toll-like receptor signaling pathway, P:regulation of transcription, DNA-templated, P:response to cAMP, P:response to ethanol, P:response to hypoxia, P:toll-like receptor 3 signaling pathway, P:toll-like receptor 4 signaling pathway, P:transcription, DNA-templated, P:TRIF-dependent toll-like receptor signaling pathway, C:intracellular, P:regulation of apoptotic process, C:CD40 receptor complex, C:internal side of plasma membrane, F:metal ion binding, P:necroptosis, P:NIK/NF-kappaB cascade, P:positive regulation of I-kappaB kinase/NF-kappaB cascade, P:proteasomal ubiquitin-dependent protein catabolic process, P:regulation of innate immune response, P:regulation of transcription, DNA-dependent, P:transcription, DNA-dependent
UniProt3D-structure, Activator, Alternative splicing, Apoptosis, Complete proteome, Cytoplasm, Ligase, Metal-binding, Nucleus, Polymorphism, Reference proteome, Repeat, Transcription, Transcription regulation, Ubl conjugation, Ubl conjugation pathway, Zinc, Zinc-finger
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)2.730.000076RNA microarray19698090

Compile date 08-10-2018© iMODE-CKD consortium