CKDdb-logoCKDdb - Molecule ID A0867

geneBIRC3, API2, IAP1
nameBaculoviral IAP repeat-containing protein 3
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
BIRC3_HUMANQ13489ENSG00000023445330Hs.127799601721

Functions and classifications

GOC:cytosol, C:membrane raft, C:nucleus, C:protein complex, F:ubiquitin-protein ligase activity, F:zinc ion binding, P:apoptotic process, P:cell surface receptor signaling pathway, P:innate immune response, P:necroptotic process, P:negative regulation of apoptotic process, P:negative regulation of necroptotic process, P:negative regulation of phosphorylation, P:negative regulation of reactive oxygen species metabolic process, P:NIK/NF-kappaB signaling, P:positive regulation of I-kappaB kinase/NF-kappaB signaling, P:positive regulation of protein ubiquitination, P:protein heterooligomerization, P:regulation of cysteine-type endopeptidase activity, P:regulation of inflammatory response, P:regulation of necroptotic process, P:regulation of nucleotide-binding oligomerization domain containing signaling pathway, P:regulation of RIG-I signaling pathway, P:regulation of toll-like receptor signaling pathway, P:spermatogenesis, P:toll-like receptor 3 signaling pathway, P:toll-like receptor 4 signaling pathway, P:TRIF-dependent toll-like receptor signaling pathway, C:cytoplasm, F:metal ion binding, P:necroptosis, P:negative regulation of necroptosis, P:NIK/NF-kappaB cascade, P:positive regulation of I-kappaB kinase/NF-kappaB cascade, P:regulation of innate immune response, C:intracellular, P:regulation of apoptotic process
UniProt3D-structure, Apoptosis, Chromosomal rearrangement, Complete proteome, Cytoplasm, Ligase, Metal-binding, Nucleus, Polymorphism, Reference proteome, Repeat, Ubl conjugation, Ubl conjugation pathway, Zinc, Zinc-finger
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)2.320.000692RNA microarray19698090
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)7.17< 0.05RNA microarray21752957
Exp22266139Homo sapiens kidneyproximal tubule epithelial cellsDiabetes (diabetic nephropathy)0.264.29E-15NGS, RNA-seq.22266139
Exp23505438bHomo sapiens kidneyproximal tubular cellsDiabetes (diabetic nephropathy)1.770.019cDNA microarray23505438
Exp23757392aRattus norvegicus17kidneywholeDiabetes (diabetic nephropathy)3.96< 0.05RNA-seq23757392
Exp23757392bRattus norvegicus13kidneywholeDiabetes (diabetic nephropathy)2.16< 0.05RNA-seq23757392
Exp24172336Mus musculus6kidneycortexAKI (AKI)10000.049762673LC-MS/MS24172336
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.130.013999RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium