CKDdb-logoCKDdb - Molecule ID A0863

geneCASP2, ICH1, NEDD2
nameCaspase-2 precursor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
CASP2_HUMANP42575ENSG00000106144835Hs.368982600639

Functions and classifications

GOC:cytosol, C:membrane, C:mitochondrion, C:nucleus, F:cysteine-type endopeptidase activity, F:cysteine-type endopeptidase activity involved in apoptotic process, F:enzyme binding, P:aging, P:brain development, P:cellular response to mechanical stimulus, P:DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest, P:execution phase of apoptosis, P:extrinsic apoptotic signaling pathway in absence of ligand, P:germ cell programmed cell death, P:intrinsic apoptotic signaling pathway in response to DNA damage, P:luteolysis, P:neural retina development, P:neurotrophin TRK receptor signaling pathway, P:positive regulation of apoptotic process, P:positive regulation of apoptotic signaling pathway, P:positive regulation of neuron apoptotic process, P:protein processing, P:proteolysis, P:regulation of cysteine-type endopeptidase activity involved in apoptotic process, P:apoptotic process, C:intracellular, P:regulation of apoptotic process, P:apoptotic signaling pathway, P:induction of apoptosis, P:nerve growth factor receptor signaling pathway, P:proteolysis, P:negative regulation of apoptotic process
UniProt3D-structure, Acetylation, Alternative splicing, Apoptosis, Complete proteome, Hydrolase, Phosphoprotein, Polymorphism, Protease, Reference proteome, Thiol protease, Zymogen
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp19698090aHomo sapiens17bloodmononuclear cellsChronic_Renal_Insufficiency (Chronic kidney disease)0.410.0069602RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.270.00107RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.30.000565RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.380.00779RNA microarray19698090
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.40.00763RNA microarray19698090
Exp25770168Homo sapiens17bloodmononuclear cellsGlomerulonephritis (IgA nephropathy)5.280.003RNA microarray25770168
Exp26317775bHomo sapiens8kidneybiopsy specimensChronic_Renal_Insufficiency (CKD)0.170.01415RNA microarray26317775

Compile date 08-10-2018© iMODE-CKD consortium