CKDdb-logoCKDdb - Molecule ID A0844

geneARHGEF1
nameRho guanine nucleotide exchange factor 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ARHG1_HUMANQ92888ENSP000003372619138Hs.631550601855

Functions and classifications

GOC:cytosol, C:plasma membrane, F:GTPase activator activity, F:Rho guanyl-nucleotide exchange factor activity, P:cell proliferation, P:negative regulation of axonogenesis, P:neurotrophin TRK receptor signaling pathway, P:positive regulation of GTPase activity, P:Rho protein signal transduction, P:termination of G-protein coupled receptor signaling pathway, P:regulation of Rho GTPase activity, C:cytoplasm, F:phospholipid binding, P:nerve growth factor receptor signaling pathway, P:regulation of Rho protein signal transduction, C:intracellular
UniProt3D-structure, Alternative splicing, Coiled coil, Complete proteome, Cytoplasm, GTPase activation, Guanine-nucleotide releasing factor, Membrane, Phosphoprotein, Polymorphism, Reference proteome
PADBmodulator, regulator

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17183245Homo sapiens24kidneyproximal tubuleproteinuria (proteinuric nephropathies)0.16< 0.05cDNA microarrays17183245
Exp19836472Mus musculus kidneytubule cellsDiabetes (Diabetic Nephropathy)5.7 LC-MS/MS19836472
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)0.31< 0.05RNA microarray21752957

Compile date 08-10-2018© iMODE-CKD consortium