CKDdb-logoCKDdb - Molecule ID A0843

geneARHGEF2, LFP40
nameGuanine nucleotide exchange factor GEF-H1
speciesHomo sapiens

Molecule reference


Functions and classifications

GOC:cytoplasmic membrane-bounded vesicle, C:cytosol, C:dendritic shaft, C:Golgi apparatus, C:microtubule, C:neuronal cell body, C:ruffle membrane, C:spindle, C:tight junction, C:vesicle, F:microtubule binding, F:Rac GTPase binding, F:Rac guanyl-nucleotide exchange factor activity, F:transcription factor binding, F:zinc ion binding, P:actin filament organization, P:apoptotic signaling pathway, P:cell morphogenesis, P:cellular hyperosmotic response, P:cellular response to muramyl dipeptide, P:cellular response to tumor necrosis factor, P:establishment of mitotic spindle orientation, P:innate immune response, P:intracellular protein transport, P:mitosis, P:negative regulation of extrinsic apoptotic signaling pathway via death domain receptors, P:negative regulation of intrinsic apoptotic signaling pathway in response to osmotic stress, P:negative regulation of microtubule depolymerization, P:negative regulation of necrotic cell death, P:negative regulation of neurogenesis, P:neurotrophin TRK receptor signaling pathway, P:positive regulation of apoptotic process, P:positive regulation of interleukin-6 production, P:positive regulation of NF-kappaB transcription factor activity, P:positive regulation of peptidyl-tyrosine phosphorylation, P:positive regulation of transcription from RNA polymerase II promoter, P:positive regulation of tumor necrosis factor production, P:regulation of cell proliferation, P:small GTPase mediated signal transduction, F:metal ion binding, F:Rho guanyl-nucleotide exchange factor activity, P:intracellular signal transduction, P:regulation of Rho GTPase activity, F:phospholipid binding, P:apoptotic process, P:cell division, P:nerve growth factor receptor signaling pathway, P:regulation of Rho protein signal transduction, C:intracellular
UniProtAcetylation, Alternative splicing, Cell cycle, Cell division, Cell junction, Cell membrane, Cell projection, Coiled coil, Complete proteome, Cytoplasm, Cytoplasmic vesicle, Cytoskeleton, Golgi apparatus, Guanine-nucleotide releasing factor, Immunity, Innate immunity, Membrane, Metal-binding, Microtubule, Mitosis, Phosphoprotein, Reference proteome, Tight junction, Zinc, Zinc-finger
PADBmodulator, regulator

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp18354378Homo sapiens8kidneyepithelial cellsureteral_obstruction (unilateral ureteral obstruction)4.408 +/- 1.094< 0.05RNA microarray18354378
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.370.000000011RNA microarray19698090
Exp25770168Homo sapiens17bloodmononuclear cellsGlomerulonephritis (IgA nephropathy)6.060.001RNA microarray25770168

Compile date 08-10-2018© iMODE-CKD consortium