CKDdb-logoCKDdb - Molecule ID A0813

nameBeta-adrenergic receptor kinase 1
speciesHomo sapiens

Molecule reference


Functions and classifications

GOC:cytosol, C:plasma membrane, F:alpha-2A adrenergic receptor binding, F:ATP binding, F:beta-adrenergic receptor kinase activity, F:Edg-2 lysophosphatidic acid receptor binding, F:G-protein coupled receptor kinase activity, P:activation of phospholipase C activity, P:cardiac muscle contraction, P:desensitization of G-protein coupled receptor protein signaling pathway, P:epidermal growth factor receptor signaling pathway, P:fibroblast growth factor receptor signaling pathway, P:G-protein coupled acetylcholine receptor signaling pathway, P:heart development, P:innate immune response, P:negative regulation of striated muscle contraction, P:negative regulation of the force of heart contraction by chemical signal, P:neurotrophin TRK receptor signaling pathway, P:peptidyl-serine phosphorylation, P:peptidyl-threonine phosphorylation, P:positive regulation of catecholamine secretion, P:receptor internalization, P:tachykinin receptor signaling pathway, P:termination of G-protein coupled receptor signaling pathway, F:protein serine/threonine kinase activity, P:signal transduction, C:apical plasma membrane, C:axon, C:basolateral plasma membrane, C:caveola, C:dendritic shaft, C:dendritic spine, C:synapse, F:phospholipid binding, P:aging, P:follicle-stimulating hormone signaling pathway, P:nerve growth factor receptor signaling pathway, P:response to hydrogen peroxide, P:response to organic cyclic compound
UniProt3D-structure, ATP-binding, Complete proteome, Kinase, Nucleotide-binding, Phosphoprotein, Polymorphism, Reference proteome, Serine/threonine-protein kinase, Transferase, Receptor
PADBenzyme, enzymatic properties

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17327501aMus musculus6kidneywholeIAKI (Ischemic acute kidney injury)3.81< 0.05RNA microarray17327501
Exp17327501bMus musculus6kidneywholeIAKI (Ischemic acute kidney injury)100.43< 0.05RNA microarray17327501
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.420.000000534RNA microarray19698090
Exp24172336Mus musculus6kidneycortexAKI (AKI)10000.049762673LC-MS/MS24172336

Compile date 08-10-2018© iMODE-CKD consortium