CKDdb-logoCKDdb - Molecule ID A0812

geneADRB2, ADRB2R, B2AR
nameBeta-2 adrenergic receptor
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
ADRB2_HUMANP07550ENSG00000169252154Hs.2551109690

Functions and classifications

GOC:apical plasma membrane, C:endosome, C:integral component of plasma membrane, C:lysosome, C:nucleus, C:receptor complex, F:beta2-adrenergic receptor activity, F:norepinephrine binding, F:potassium channel regulator activity, F:protein homodimerization activity, P:activation of adenylate cyclase activity, P:activation of transmembrane receptor protein tyrosine kinase activity, P:adenylate cyclase-activating G-protein coupled receptor signaling pathway, P:adenylate cyclase-modulating G-protein coupled receptor signaling pathway, P:bone resorption, P:brown fat cell differentiation, P:desensitization of G-protein coupled receptor protein signaling pathway by arrestin, P:diet induced thermogenesis, P:endosome to lysosome transport, P:heat generation, P:negative regulation of multicellular organism growth, P:negative regulation of smooth muscle contraction, P:positive regulation of bone mineralization, P:positive regulation of MAPK cascade, P:positive regulation of protein ubiquitination, P:positive regulation of transcription from RNA polymerase II promoter, P:receptor-mediated endocytosis, P:regulation of sodium ion transport, P:regulation of vasodilation, P:response to cold, P:vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure, C:integral component of membrane, P:adrenergic receptor signaling pathway, C:apical plasma membrane, C:axon, C:caveola, C:dendritic spine, C:integral to plasma membrane, C:neuronal cell body membrane, C:sarcolemma, F:dopamine binding, F:drug binding, F:epinephrine binding, P:diaphragm contraction, P:negative regulation of inflammatory response, P:negative regulation of ossification, P:negative regulation of urine volume, P:positive regulation of apoptotic process, P:positive regulation of cell proliferation, P:positive regulation of potassium ion transport, P:positive regulation of skeletal muscle tissue growth, P:positive regulation of sodium ion transport, P:positive regulation of the force of heart contraction by epinephrine, P:positive regulation of vasodilation, P:regulation of excitatory postsynaptic membrane potential, P:regulation of sensory perception of pain, P:synaptic transmission, glutamatergic, P:wound healing, C:integral to membrane
UniProt3D-structure, Cell membrane, Complete proteome, Disulfide bond, G-protein coupled receptor, Glycoprotein, Hydroxylation, Lipoprotein, Membrane, Palmitate, Phosphoprotein, Polymorphism, Receptor, Reference proteome, Transducer, Transmembrane, Transmembrane helix, Ubl conjugation
PADBreceptor

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp21752957aHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.62< 0.05RNA microarray21752957
Exp21752957bHomo sapiens22kidneytubuliDiabetes (diabetic kidney disease)3.31< 0.05RNA microarray21752957
Exp23505438aHomo sapiens kidneyproximal tubular cellsDiabetes (diabetic nephropathy)2.130.009cDNA microarray23505438
Exp23505438bHomo sapiens kidneyproximal tubular cellsDiabetes (diabetic nephropathy)1.360.002cDNA microarray23505438

Compile date 08-10-2018© iMODE-CKD consortium