CKDdb-logoCKDdb - Molecule ID A0811

geneKCNJ1, ROMK1
nameATP-sensitive inward rectifier potassium channel 1
speciesHomo sapiens

Molecule reference

SwissProtUniProtEnsEMBLGeneIDUniGeneOMIM
IRK1_HUMANP48048ENSG000001517043758Hs.527830241200, 600359

Functions and classifications

GOC:voltage-gated potassium channel complex, F:ATP binding, F:inward rectifier potassium channel activity, F:phosphatidylinositol-4,5-bisphosphate binding, P:cardiovascular system development, P:excretion, P:kidney development, P:post-embryonic development, P:regulation of G-protein activated inward rectifier potassium channel activity, P:renal sodium ion absorption, P:synaptic transmission, P:tissue homeostasis, C:integral component of membrane, P:potassium ion transmembrane transport, C:voltage-gated potassium channel complex, C:integral to membrane
UniProtAlternative splicing, ATP-binding, Bartter syndrome, Cell membrane, Complete proteome, Disease mutation, Glycoprotein, Ion channel, Ion transport, Membrane, Nucleotide-binding, Phosphoprotein, Polymorphism, Potassium, Potassium transport, Reference proteome, Transmembrane, Transmembrane helix, Transport, Voltage-gated channel
PADBchannel

Studies, tissues and diseases

Study IDSpeciesNTissue / SourceCompartmentDiseaseFold change in diseaseP-valueDetectionPubMed/DOI
Exp17003339aMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)0.88< 0.05cDNA microarray17003339
Exp17003339bMus musculus24kidneyglomeruliDiabetes (diabetic nephropathy)2.11< 0.05cDNA microarray17003339
Exp19346236Homo sapiens10kidneycystsPolycystic_Kidney_Disease (Autosomal dominant polycystic kidney disease)00.005mRNA microarray19346236
Exp19698090bHomo sapiens25bloodmononuclear cellsDialysis (hemodialysis)0.250.000707RNA microarray19698090
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.324.60E-05RNA microarray20019191
Exp20019191Homo sapiens18kidneyglomeruliNephrosclerosis (glomerulosclerosis)1.432.62E-05RNA microarray20019191
Exp23760282aMus musculus kidneywholeureteral_obstruction (renal tubulointerstitial injury)2.690.026RNA microarray23760282
Exp23935909Homo sapiens24bloodmonocytesChronic_Renal_Insufficiency (Chronic kidney disease)0.180.0034936RNA microarray23935909
Exp24569379Mus musculus kidneyendothelial cellsAKI (AKI)0.196.36E-08RNA microarray24569379

Compile date 08-10-2018© iMODE-CKD consortium